The authors show that α-synuclein is an amphiphile for condensates and localizes to the condensate surface by reversible adsorption into multiple, heterogeneous layers, driven by surface charge. The adsorption can be modulated by biomolecules, including RNA, proteins and lipids, which slows down α-synuclein aggregation.
- Brent S. Visser
- Merlijn H. I. van Haren
- Evan Spruijt
