Despite not conserved in all mammals, TRIM52 is crucial for fitness in human cells. Here, the authors show that TRIM52 interacts with the DNA repair machinery to prevent cell-cycle arrest, and that TRIM52 is rapidly degraded by multiple giant E3 ligases. These findings link TRIM52 to genome integrity control.
- Alexandra Shulkina
- Kathrin Hacker
- Gijs A. Versteeg
