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Showing 1–4 of 4 results
Advanced filters: Author: Valeria Cassina Clear advanced filters
  • Microbial colonization and biofilm formation drive persistent infections on medical devices, often under fluid flow. Here, the authors engineer buckling-induced wrinkled and folded patterns with precisely defined geometries, integrate them into microfluidic channels, and show how wrinkling instabilities can be exploited to mitigate bacterial colonization under dynamic conditions.

    • Luca Pellegrino
    • Giovanni Savorana
    • Roberto Rusconi
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15
  • Primary cilia are shown to adjust length in response to cellular nutrient availability, with a special role for glutamine-mediated anaplerosis via the enzyme ASNS, which was found to be located at the base of cilia. Consistently, cells lacking cilia show an altered response to glutamine during metabolic stress.

    • Maria Elena Steidl
    • Elisa A. Nigro
    • Alessandra Boletta
    ResearchOpen Access
    Nature Metabolism
    Volume: 5, P: 385-397
  • ETNK1 mutations are recurrent in leukemia but how they contribute to oncogenesis is still unclear. Here, the authors show that ETNK1 mutations increase mitochondrial activity, ROS and H2AX levels and that these effects can be rescued upon phosphoethanolamine supplementation.

    • Diletta Fontana
    • Mario Mauri
    • Rocco Piazza
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • Polycystic kidney disease is marked by progressive growth of renal tubular epithelia and thus the formation of pathological cysts in the organ over time. Alessandra Boletta and her colleagues now show that this cystic growth has the hallmarks of the Warburg effect (that is, the primary reliance of cells on glycolysis for their energy demands) and that blocking this effect in vivo is sufficient to improve disease progression in two mouse models.

    • Isaline Rowe
    • Marco Chiaravalli
    • Alessandra Boletta
    Research
    Nature Medicine
    Volume: 19, P: 488-493