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Showing 1–3 of 3 results
Advanced filters: Author: Valerie Rezek Clear advanced filters

  • Here the authors engineer a bispecific antibody (Ab) for HIV-1 by combining a gp41 N-heptad repeat targeting Ab with a CD4 binding Ab. Prepositioning via CD4 binding results in high neutralization breadth and potency, and experiments in HIV infected humanized male mice show reduction of viral load.

    • Soohyun Kim
    • Caelan E. Radford
    • Peter S. Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Yang and colleagues have previously reported a clinically guided culture method to generate allogeneic CAR-NKT cells by engineering human hematopoietic stem and progenitor cells. As potential application, here the authors describe the design and characterization of allogeneic CD33-targeting CAR-NKT cells, showing anti-tumor activity in preclinical models of bone marrow-resident myeloid malignancies.

    • Yan-Ruide Li
    • Ying Fang
    • Lili Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-28

  • MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.

    • Júlia Aguadé-Gorgorió
    • Yasaman Jami-Alahmadi
    • Hanna K. A. Mikkola
    ResearchOpen Access
    Nature
    Volume: 630, P: 412-420