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Showing 1–2 of 2 results
Advanced filters: Author: Vasyl Nesin Clear advanced filters

  • The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.

    • Prabir K. Chakraborty
    • Soumyajit Banerjee Mustafi
    • Priyabrata Mukherjee
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Seokho et al. report that Wnt ligands bind the extracellular domain of polycystin 1 (PKD1) and induce Ca2+ influx through the Ca2+-permeable ion channel TRPP2. This activity is abrogated by PKD1 mutations linked to polycystic kidney disease.

    • Seokho Kim
    • Hongguang Nie
    • Leonidas Tsiokas
    Research
    Nature Cell Biology
    Volume: 18, P: 752-764