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Showing 1–6 of 6 results
Advanced filters: Author: Verónica Casquero-Garcia Clear advanced filters

  • High mitogenic stimuli have been suggested to promote endothelial cell proliferation and sprouting during angiogenesis. Here Pontes-Quero et al., by interfering with levels of VEGF and Notch signalling in single endothelial cells in vivo, find that high mitogenic stimuli instead arrest angiogenesis due to a bell-shaped dose-response to VEGF and MAPK activity that is counteracted by Notch and p21.

    • Samuel Pontes-Quero
    • Macarena Fernández-Chacón
    • Rui Benedito
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • The Cre-Lox system allows high spatiotemporal control of genetic modifications. Here the authors present iSuRe-Cre that significantly increases Cre activity in reporter expressing cells, which ultimately increases the efficiency and reliability of Cre-dependent reporter and gene function analysis.

    • Macarena Fernández-Chacón
    • Verónica Casquero-García
    • Rui Benedito
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Fernández-Chacón et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.

    • Macarena Fernández-Chacón
    • Severin Mühleder
    • Rui Benedito
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 530-549

  • Arterial development relies on the timely and MYC-dependent suppression of endothelial metabolism and the cell cycle in pre-arterial endothelial cells through Notch signalling.

    • Wen Luo
    • Irene Garcia-Gonzalez
    • Rui Benedito
    Research
    Nature
    Volume: 589, P: 437-441