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Showing 1–14 of 14 results
Advanced filters: Author: Vicki H. Wysocki Clear advanced filters

  • Hetero-oligomeric proteins offer many advantages for bioengineering efforts but are difficult to make from scratch. Here, authors present a simple method for creating pseudosymmetric hetero-oligomers from input symmetrical proteins.

    • Ryan D. Kibler
    • Sangmin Lee
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • The authors stabilize the SARS-CoV-2 nucleocapsid (N) dimer assembly using a short RNA and chemical crosslinker for EM analysis, revealing its domain arrangement and antigenic sites to advance understanding and guide pan-coronavirus therapeutic design.

    • Sara Landeras-Bueno
    • Chitra Hariharan
    • Erica Ollmann Saphire
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In their natural environment, membrane proteins are surrounded by lipids, but the effect that the lipids have on the proteins is not easy to assess. Now, controlling the extent of delipidation has enabled the study of these interactions.

    • Sophie R. Harvey
    • Vicki H. Wysocki
    News & Views
    Nature Chemistry
    Volume: 7, P: 189-190

  • The Gabija system constitutes one of the most prevalent anti-phage defense systems and is composed of GajA and GajB. Here, using cryo-EM and biochemistry, the authors show that GajA and GajB form a supramolecular complex with a stoichiometry of 4:4 to promote anti-phage defense.

    • Xiao-Yuan Yang
    • Zhangfei Shen
    • Tian-Min Fu
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 1243-1250

  • Using cryo-electron microscopy the authors show that PtuA, an ATPase, and PtuB, a nuclease, assemble into a supramolecular complex with a stoichiometry of 6:2 for anti-phage defense in bacteria. Nucleoside triphosphates inhibit PtuAB activity while phage infection activates PtuAB to cleave phage genome for immune defense.

    • Yuanyuan Li
    • Zhangfei Shen
    • Yamei Yu
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 413-423

  • Two de novo designed protein classes that link phosphorylation by tyrosine and serine kinases to protein-protein association provide potential new avenues to regulating cell function.

    • Nicholas B. Woodall
    • Zara Weinberg
    • David Baker
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 762-770

  • Specific ssDNA binding proteins promote the annealing of complementary strands. Here the authors reveal an intermediate of annealing in which a duplex DNA is bound in an unusual conformation that is highly extended and unwound for the ssDNA binding protein Redβ from bacteriophage λ.

    • Brian J. Caldwell
    • Andrew S. Norris
    • Charles E. Bell
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • ABC-type heterotrimeric proteins can be designed de novo using coiled coils and helical bundles as starting scaffolds, extended using helical repeat proteins and then used as building blocks for higher-order oligomeric assemblies.

    • Sherry Bermeo
    • Andrew Favor
    • David Baker
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 29, P: 1266-1276

  • Significant challenges exist for structural characterization of enzymes responsible for biomineralization. Here the authors show that native mass spectrometry and high resolution electron microscopy can define the subunit topology and copper binding of a manganese oxidizing complex, and describe early stage formation of its mineral products

    • Christine A. Romano
    • Mowei Zhou
    • Bradley M. Tebo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8

  • Collision cross sections (CCS) from ion mobility mass spectrometry provide information about protein shape and size. Here, the authors develop an algorithm to predict CCS and integrate experimental ion mobility data into Rosetta-based molecular modelling to predict protein structures from sequence.

    • SM Bargeen Alam Turzo
    • Justin T. Seffernick
    • Steffen Lindert
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15