TWIK-2 is an endolysosomal potassium channel implicated in inflammatory responses. Here, authors present a cryo-EM structure of human TWIK-2 and establish a high-throughput automated patch-clamp electrophysiology assay to investigate modulation of TWIK-2.
- Qianqian Ma
- Ciria C. Hernandez
- Shyamal Mosalaganti