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Showing 1–5 of 5 results
Advanced filters: Author: Ville Hoikkala Clear advanced filters

  • Ring nucleases are enzymes that degrade cyclic nucleotide signalling molecules generated by prokaryotic antiviral systems. Chi et al. report the structure and mechanism of a new class of ring nuclease, Crn4, with a very broad substrate specificity.

    • Haotian Chi
    • Ville Hoikkala
    • Malcolm F. White
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-10

  • It is unknown what circumstances promote particular bacterial defenses against bacterial viruses (phages). Almeida & Hoikkala et al. show that mucin, derived from mucus, greatly accelerates CRISPR-Cas defenses against phage in an opportunistic pathogen.

    • Gabriel Magno de Freitas Almeida
    • Ville Hoikkala
    • Lotta-Riina Sundberg
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The Bacteroides fragilis type III CRISPR protein Cmr conjugates ATP to S-adenosyl methionine, generating S-adenosyl methionine (SAM)-AMP, a novel second messenger with a role in antiviral signalling.

    • Haotian Chi
    • Ville Hoikkala
    • Malcolm F. White
    ResearchOpen Access
    Nature
    Volume: 622, P: 826-833

  • Arms races between phage and bacteria are well known from lab experiments, but insight from field systems is limited. Here, the authors show changes in the resistance and CRISPR loci of bacteria and the infectivity, host range and genome size of phage over multiple years in an aquaculture environment.

    • Elina Laanto
    • Ville Hoikkala
    • Lotta-Riina Sundberg
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8