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Showing 1–8 of 8 results
Advanced filters: Author: Vincent A. Blomen Clear advanced filters

  • Lysosomal phospholipase PLA2G15 was identified as a physiological BMP hydrolase whose activity depends on unique esterification and stereochemistry of BMP and offers a potential therapeutic target for Niemann–Pick disease type C1 and other neurodegenerative conditions.

    • Kwamina Nyame
    • Jian Xiong
    • Monther Abu-Remaileh
    ResearchOpen Access
    Nature
    Volume: 642, P: 474-483

  • The link between 3D genome architecture and gene expression is still far from resolved. Here the authors show that loss of the CDK catalytic subunit of the Mediator complex results in heterochromatic silencing, which can be rescued by stabilization of cohesin on chromatin.

    • Judith H. I. Haarhuis
    • Robin H. van der Weide
    • Elzo de Wit
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Carette et al. use a retroviral gene-trap vector to disrupt and tag >98% of all genes in a haploid human cancer cell line. Cells selected for a phenotype of interest are pooled and characterized by parallel DNA sequencing to circumvent time- and labor-intensive screening of individual clones.

    • Jan E Carette
    • Carla P Guimaraes
    • Thijn R Brummelkamp
    Research
    Nature Biotechnology
    Volume: 29, P: 542-546

  • A haploid screen in human cells identified the solute carrier protein family member, SLC35F2, as a determinant of the sensitivity of cells to the DNA damaging agent, YM155, by promoting YM155 import into cells.

    • Georg E Winter
    • Branka Radic
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 10, P: 768-773

  • A collection of single-gene-mutant human cells is described. This growing resource is based on gene-trap mutagenesis of a near-haploid human cell line and covers almost 3,500 human genes.

    • Tilmann Bürckstümmer
    • Carina Banning
    • Sebastian M B Nijman
    Research
    Nature Methods
    Volume: 10, P: 965-971