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Showing 1–4 of 4 results
Advanced filters: Author: Virginia Spanoudaki Clear advanced filters

  • Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix binding affect anti-tumor immune response and report a pharmacokinetic framework to predict response to intratumoral IL-2 therapy.

    • Noor Momin
    • Joseph R. Palmeri
    • K. Dane Wittrup
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Sivanand et al. survey different types of cancers and study how the metabolic profile of the primary cancer site influences the metabolism of the metastatic cells, thus influencing sites of metastasis.

    • Sharanya Sivanand
    • Yetis Gultekin
    • Matthew G. Vander Heiden
    Research
    Nature Metabolism
    Volume: 6, P: 1668-1681