Nature Search

Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial

In a double-blind, placebo-controlled phase 2 trial in patients with metastatic renal cell carcinoma treated with anti-PD-1 plus a VEGFR tyrosine kinase inhibitor, donor fecal microbial transplantation (FMT) from complete responders to immunotherapy did not significantly improve the primary endpoint of 12-month progression-free survival (PFS) but did significantly improve median PFS versus placebo FMT.

Serena Porcari
Chiara Ciccarese
Gianluca Ianiro
ResearchOpen Access28 Jan 2026
Nature Medicine

P: 1-9
Baby-to-baby strain transmission shapes the developing gut microbiome

A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infant microbiome development.

Liviana Ricci
Vitor Heidrich
Nicola Segata
ResearchOpen Access21 Jan 2026
Nature

P: 1-10
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial

In a phase 2 trial evaluating healthy donor fecal microbial transplantation plus either anti-PD-1 in patients with non-small cell lung cancer or anti-PD-1 and anti-CTLA-4 in patients with melanoma, encouraging efficacy was seen in both cohorts, with responses linked to significantly greater loss of baseline bacterial species.

Sreya Duttagupta
Meriem Messaoudene
Arielle Elkrief
ResearchOpen Access28 Jan 2026
Nature Medicine

P: 1-14
Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer

An analysis of 18 metagenomic datasets of individuals with colorectal cancer, adenomas and healthy controls yields improved cancer prediction accuracy based solely on gut metagenomics, as well as the identification of new species associated with the development of cancer.

Gianmarco Piccinno
Kelsey N. Thompson
Nicola Segata
ResearchOpen Access03 Jun 2025
Nature Medicine

Volume: 31, P: 2416-2429
Human microbiome acquisition and transmission

Each human hosts a unique microbiome, but only recently have we started to uncover how such uniqueness can arise. In this Review, Heidrich, Valles-Colomer and Segata highlight studies that surveyed how we acquire and transmit our microbiome strains through interactions with other humans and the environment.

Vitor Heidrich
Mireia Valles-Colomer
Nicola Segata
Reviews21 Mar 2025
Nature Reviews Microbiology

Volume: 23, P: 568-584
Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders

Here, Manghi et al. identify potential salivary microbial biomarkers for autism through a large-scale metagenomic analysis of 2,000 families, revealing shifts in neurotransmitter-related pathways

Paolo Manghi
Michele Filosi
Enrico Domenici
ResearchOpen Access11 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals

Using 21,561 individuals, the authors present a cross-sectional study of how gut microbiome signatures are associated with dietary intake patterns and with host health outcomes.

Gloria Fackelmann
Paolo Manghi
Nicola Segata
ResearchOpen Access06 Jan 2025
Nature Microbiology

Volume: 10, P: 41-52
Newly identified species from the dog dental plaque microbiome highlight little overlap with humans

Vitor Heidrich
Gloria Fackelmann
Nicola Segata
ResearchOpen Access18 Feb 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-6
Commensal oral microbiota impacts ulcerative oral mucositis clinical course in allogeneic stem cell transplant recipients

Julia S. Bruno
Vitor Heidrich
Eduardo R. Fregnani
ResearchOpen Access20 Oct 2022
Scientific Reports

Volume: 12, P: 1-9
Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantation

Vinícius Campos de Molla
Vitor Heidrich
Celso Arrais-Rodrigues
ResearchOpen Access02 Sept 2021
Scientific Reports

Volume: 11, P: 1-11
Favorable subgingival plaque microbiome shifts are associated with clinical treatment for peri-implant diseases

Davide Bazzani
Vitor Heidrich
Paolo Ghensi
ResearchOpen Access19 Feb 2024
npj Biofilms and Microbiomes

Volume: 10, P: 1-6

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