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Showing 1–13 of 13 results
Advanced filters: Author: Vladimir Tesar Clear advanced filters

  • Proliferative lupus nephritis is the most severe form of lupus nephritis. Outcomes of patients with proliferative lupus nephritis improved dramatically following the introduction of corticosteroids and cyclophosphamide, but many patients still develop end-stage renal disease. In this Review, Tesar and Hruskova discuss the clinical course of lupus nephritis, factors that predict outcomes, current induction and maintenance treatments, and recent advances in treatment options.

    • Vladimir Tesar
    • Zdenka Hruskova
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 96-109

  • Here, the authors provide guidance on the prevention, diagnosis and management of anticancer therapy nephrotoxicity in adult patients. They also define a research agenda focused on preventing and mitigating anticancer therapy toxicity, maximizing early detection of nephrotoxicity and enabling optimal drug dosing in patients with kidney disease.

    • Amanda DeMauro Renaghan
    • Marlies Ostermann
    • Mitchell H. Rosner
    Reviews
    Nature Reviews Nephrology
    Volume: 22, P: 283-300

  • Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

    • Paul A Lyons
    • James E Peters
    • Kenneth G. C. Smith
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Pathology diagnostics still rely on tissue morphology assessment by trained experts. Here, the authors perform deep-learning-based segmentation followed by large-scale feature extraction of histological images, i.e., next-generation morphometry, to enable outcome-relevant and disease-specific pathomics analysis of non-tumor kidney pathology.

    • David L. Hölscher
    • Nassim Bouteldja
    • Peter Boor
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • Lili Liu
    • Krzysztof Kiryluk
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Ali Gharavi and colleagues report a genome-wide association analysis of IgA nephropathy in over 20,000 individuals of European and East Asian ancestry. They identify genome-wide significant signals at three new loci near VAV3, CARD9 and ITGAM-ITGAX and correlations between genetic risk and pathogen diversity.

    • Krzysztof Kiryluk
    • Yifu Li
    • Ali G Gharavi
    Research
    Nature Genetics
    Volume: 46, P: 1187-1196

  • IgA nephropathy (IgAN) is an inflammatory disease of the glomerulus that can lead to kidney failure. In this Primer, Stamellou et al. discuss the prevalence and pathophysiological mechanisms of IgAN, summarize diagnosis and management of the disease, and provide an outlook on required future research.

    • Eleni Stamellou
    • Claudia Seikrit
    • Rafael Kramann
    Reviews
    Nature Reviews Disease Primers
    Volume: 9, P: 1-21

  • Kidney disease risk and outcomes are strongly associated with inequities that occur across the entire clinical course of the disease. The authors of this Review describe the different inequities that affect kidney health and care worldwide, and consider potential solutions to help to mitigate these.

    • Raymond Vanholder
    • Lieven Annemans
    • Valérie A. Luyckx
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 694-708

  • In this Review, the authors summarize the challenges associated with the care of patients with kidney disease during the COVID-19 pandemic. They describe the major challenges and missed opportunities, global inequalities in health care, and offer a framework for future pandemic preparedness.

    • Duvuru Geetha
    • Andreas Kronbichler
    • Valerie Luyckx
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 724-737