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Showing 1–6 of 6 results
Advanced filters: Author: Volker Derdau Clear advanced filters

  • Deuterated compounds find applications in a variety of fields including catalysis optimization, mass spectrometry standards, pharmaceutical development and organic light emitting diodes. A recent study indicates that the choice of deuterium source significantly affects both the outcomes and mechanistic pathways in catalytic cycles.

    • Volker Derdau
    News & Views
    Nature Catalysis
    Volume: 8, P: 1264-1265

  • Deuterated compounds are used in many applications such as mass-spectrometry standards, drugs or in organic light-emitting diodes. Now, hydrogen-activated homogeneous pincer complex catalysts can be used to perform selective alkene deuteration with the cheapest available deuterium source, D2O.

    • Anika Tarasewicz
    • Volker Derdau
    News & Views
    Nature Chemistry
    Volume: 15, P: 1332-1333

  • A photochemical method alters thiazole and isothiazole structures predictably that enables selective rearrangements and expanding accessible derivatives, thereby advancing drug and agrochemical discoveries under mild conditions.

    • Baptiste Roure
    • Maialen Alonso
    • Daniele Leonori
    ResearchOpen Access
    Nature
    Volume: 637, P: 860-867

  • Human glucose transporters (GLUTs), particularly GLUT1 and GLUT3, are potential anticancer therapy targets. Here, Nan Wang et al. use an engineered GLUT 3 variant to identify an exofacial GLUT3 inhibitor, SA47, and elucidate the drug’s inhibitory mechanism.

    • Nan Wang
    • Shuo Zhang
    • Nieng Yan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Carbon-labelled α-amino acids are valuable compounds in drug development and nuclear medicine, but are difficult and time consuming to prepare. Now, an aldehyde-catalysed method has been developed for the direct C1-labelling of α-amino acids using *CO2 (* = 14, 13, 11), providing access to many proteinogenic and non-natural labelled α-amino acids.

    • Odey Bsharat
    • Michael G. J. Doyle
    • Rylan J. Lundgren
    Research
    Nature Chemistry
    Volume: 14, P: 1367-1374