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Showing 1–7 of 7 results
Advanced filters: Author: W. Mike Henne Clear advanced filters

  • Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactions with other organelles influence physiology and contribute to disease.

    • W. Mike Henne
    • Sarah Cohen
    Reviews
    Nature Reviews Molecular Cell Biology
    P: 1-17

  • Mike Henne discusses the pioneering work of Jean Vance, which revealed that mitochonodria-associated membranes (MAMs) are sites for inter-organelle phospholipid exchange and step-wise synthesis reactions.

    • W. Mike Henne
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 166

  • Phox homology (PX) domains are membrane interacting domains that bind to various lipids. Here authors screen all human PX domains systematically for their phospholipid preferences and define four classes and provide the basis for defining and predicting functional PX-membrane interactions.

    • Mintu Chandra
    • Yanni K.-Y. Chin
    • Brett M. Collins
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Lipolysis generates fatty acids that are burned in peroxisomes for energy, and dysregulation in this process creates toxic reactive oxygen species (ROS) and contributes to diseases such as non-alcoholic fatty liver disease. In this issue of Nature Metabolism, Ding et al. reveal how the peroxin PEX2 senses cellular ROS to fine-tune ATGL-mediated lipolysis.

    • Blessy Paul
    • W. Mike Henne
    News & Views
    Nature Metabolism
    Volume: 3, P: 1591-1593

  • Rupali Ugrankar et al. show that Drosophila larvae with high levels of circulating glucose, but not trehalose, don’t eat much. This study suggests that circulating glucose communicates with insulin signaling and the sodium/solute co-transporter SLC5A11 in the brain to suppress larval appetite.

    • Rupali Ugrankar
    • Pano Theodoropoulos
    • Jonathan M. Graff
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-15