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Showing 1–7 of 7 results
Advanced filters: Author: Wan-Qiu Liu Clear advanced filters

  • Reconstructing transcription–translation-coupled DNA replication (TTcDR) in artificial systems is crucial for creating synthetic life. Here the authors develop LoopReX, a TTcDR which leverages minimal machinery and artificial nucleoids to support multiple biological functions.

    • Xiao Zheng
    • Wenli Gao
    • Jian Li
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with potent biological activities but a vast majority of RiPP gene clusters remain unexplored in microbial genomes. Here, the authors report a unified biocatalysis (UniBioCat) system based on cell-free gene expression for rapid biosynthesis and engineering of RiPPs.

    • Wan-Qiu Liu
    • Xiangyang Ji
    • Jian Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Cell-free gene expression (CFE) systems are often constrained by numerous biochemical components required to maintain biocatalytic efficiency. Here, the authors propose a droplet-AI combined approach to perform high-throughput and efficient combinatorial screening of CFE. This work led to simplified CFE systems with improved yield and cost-effectiveness.

    • Jiawei Zhu
    • Yaru Meng
    • Yifan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • An understanding of the domestication of the yeast Saccharomyces cerevisiae has important implications for studying its evolution and diversity. Here, the authors show that Far East Asia is likely the center of origin of the domesticated populations of the yeast based on genomic and phenotypic characterization of a large collection of isolates.

    • Shou-Fu Duan
    • Pei-Jie Han
    • Feng-Yan Bai
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Thiopeptides such as nosiheptide are clinically-interesting antimicrobial natural products. Here the authors show the functional dissection of a series of enzymes involved in nosiheptide biosynthesis, revealing a unique biosynthetic pathway that centers on a previously-unknown carrier protein.

    • Wei Ding
    • Wenjuan Ji
    • Qi Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7