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Showing 1–2 of 2 results
Advanced filters: Author: Wangde Hua Clear advanced filters

  • α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are multifunctional carboxylic acids with diverse applications, yet their current synthetic methods remain neither environmentally friendly nor efficient. Here, the authors present a water-based synthesis of KGA and MTA using biomass-derived precursors, pyruvic acid and glyoxylic acid, through aldol condensation followed by hydrodeoxygenation reactions.

    • Cheng-Bin Hong
    • Wangde Hua
    • Haichao Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-8

  • Peptide macrocycles are uniquely suited to engage some challenging biological targets, such as protein–protein interactions. Inspired by the ‘C–H’ cross-linked peptide natural products, a highly efficient and generally applicable strategy for constructing cyclophane-braced peptide macrocycles has been developed. The strategy is based on palladium-catalysed intramolecular C(sp3)–H arylation reactions.

    • Xuekai Zhang
    • Gang Lu
    • Gong Chen
    Research
    Nature Chemistry
    Volume: 10, P: 540-548