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The SESAME complex regulates cell senescence through the generation of acetyl-CoA

Using budding yeast and human endothelial cells, Li et al. find that increased synthesis of acetyl-CoA in the nucleus promotes histone acetylation at subtelomeric regions, thus leading to telomere silencing defects and cellular senescence.

Wanping Chen
Xilan Yu
Shanshan Li
Research28 Jun 2021
Nature Metabolism

Volume: 3, P: 983-1000
Lithium enrichment in the Qarhan Salt Lake (China) was a long-term process driven by interglacial-glacial cycles

Glacial-interglacial cycles drove lithium-rich brine formation in the Qarhan Salt Lake in China, according to Th dating and fluid inclusion analyses in halite, and paleotemperature reconstructions.

Pengyu Long
Yanjun Zhao
Lisheng Wang
ResearchOpen Access21 Apr 2025
Communications Earth & Environment

Volume: 6, P: 1-11
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength

Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle causes reduced muscle mass and strength via activation of autophagy.

Zhisheng Xu
Tingting Fu
Zhenji Gan
ResearchOpen Access16 Feb 2022
Nature Communications

Volume: 13, P: 1-20
Retrospective analysis of patients with non-tuberculous mycobacteria from a primary hospital in Southeast China

Songjun Ji
Wanping Xu
Xinling Pan
ResearchOpen Access23 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy

Multi-omics approach, immunoflurescence, and scRNA-seq link CD39+ Tregs to idiopathic membranous nephropathy (IMN) risk and poor prognosis. Machine learning models based on CD39+ Treg signature genes enabling MN prediction.

Xiaoyi Song
Wen Zhu
Man Li
ResearchOpen Access10 Aug 2025
Communications Biology

Volume: 8, P: 1-14
Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling

Jiehui Di
Zhongjun Zhao
Yong Liu
ResearchOpen Access13 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-16
Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells

Andrew Sulaiman
Sarah McGarry
Lisheng Wang
ResearchOpen Access26 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-14
Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation

Bing Shu
Yongjian Zhao
Di Chen
ResearchOpen Access12 Aug 2020
Bone Research

Volume: 8, P: 1-8
Noninvasive evaluation of ¹⁸F-FDG/¹⁸F-FMISO-based Micro PET in monitoring hepatic metastasis of colorectal cancer

Mingyu Zhang
Huijie Jiang
Song Wang
ResearchOpen Access13 Dec 2018
Scientific Reports

Volume: 8, P: 1-10

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