Qin Wang et al. show that altered phosphate metabolism contributes to the progression of kidney disease using a salt-sensitive rat model. They demonstrate that using the phosphate binder sucroferric oxyhydroxide reduces kidney injury and, using transcriptome sequencing, identify a potential role for complement C1q in kidney inflammation linked to phosphate metabolism defects.
- Qin Wang
- Kenichi Ishizawa
- Shigeru Shibata
