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5-hydroxymethylcytosine analysis reveals stable epigenomic changes in tumor tissue that enable cancer detection in cell-free DNA

Analysis of 5hmC in tumor tissues and cfDNA reveals concordant cancer signatures that show potential for tissue origin prediction via liquid biopsy

Yuan Xue
Yuhong Ning
Samuel Levy
ResearchOpen Access19 Nov 2025
Communications Biology

Volume: 8, P: 1-15
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to understand in vivo protection of PfCSP-targeting antibodies.

Tossapol Pholcharee
David Oyen
Ian A. Wilson
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25

Pfs25 is a transmission-blocking vaccine candidate for Plasmodium. Here, McLeod et al. analyze the antibody response to Pfs25 in sera from a clinical trial evaluating a Pfs25 vaccine candidate, identify a potent transmission-blocking antibody and determine recognized epitopes on Pfs25.

Brandon McLeod
Kazutoyo Miura
Jean-Philippe Julien
ResearchOpen Access24 Sept 2019
Nature Communications

Volume: 10, P: 1-11

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