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Cryogenic Li | |Cl₂ batteries face severe interfacial instability. Here, authors demonstrate a solvation reconfiguration strategy to build a robust interphase, enabling stable cycling of Li | |Cl₂ batteries for over 1100 cycles at –40 °C.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Zinc isotopes in basalts along a 1,100-km transect of the Gakkel Ridge record widespread mantle recycling of surface carbonates via ancient oceanic subduction, explaining the unusually carbon-rich nature of the Arctic asthenosphere.

Organic solar cells (OSCs) rely on morphological optimization for high efficiency. The authors show cyclobutyl-mediated interchain supramolecular interactions among acceptors, suppressing electron-phonon coupling and optimizing acceptor alloy phase morphology in ternary OSCs to achieve efficiencies approaching 21%.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

Converting syngas into high-value long-chain alcohols is a major industrial challenge due to poor product selectivity. This study achieves 80% selectivity through a modular catalytic design that boosts carbon efficiency while minimizing waste.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

The authors present a multi-core neuromorphic architecture that enables energy‑efficient training of deep spiking neural networks via backpropagation. The design features a multi-engine core, multi-level parallelism, sparsity optimization, and FPGA validation.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Programmable supramolecular COF/MXene assemblies integrate convenient H₂O₂ photoproduction with photothermal units, realizing long-term O₂ capture, in situ H₂O₂ synthesis and utilization toward decentralized green chemical manufacturing.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

A “confined molecular encapsulation” strategy enables one-step fabrication of biomimetic ion-selective membranes. The in-situ formed MOFs with tunable sizes facilitate highly precise ion differentiation.

Gel-based soft materials are attractive for flexible electronics, though are constrained by unfavorable mechanical properties. Here the authors design a geometry programmed self-wrinkling strategy for organo-hydrogels, enhancing mechanical and electronic properties.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

BMP–Smad signaling is essential for mammalian primordial germ cell (PGC) fate specification, but whether BMP signaling functions in the zebrafish germline remains elusive. Here they show that BMP signaling is required for PGC proliferation but not fate specification.

Precise transcriptional regulation is critical for cellular function and development. In this study, authors unravel a regulatory compensation mechanism that ensures stable and precise transcriptional output for SIN3A, and potentially other dosage-sensitive genes.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Lead halide perovskites are promising for artificial photosynthesis but are unstable in seawater. Here, the authors report multisite atomic-chlorine passivation to stabilize CsPbI₃ quantum dots in a hydrophobic covalent organic framework, enabling efficient H₂O₂ photosynthesis directly from seawater.

Combining distinct confinement mechanisms can enable the engineering of novel electronic states. Here, the authors integrate a moiré potential with vertical quantum confinement in a heterostructure composed of twisted bilayer MoS₂ on (111)-oriented Bi nanofilms, revealing experimental signatures of a Wigner crystal.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of premature infants with unclear mechanisms. Here, the authors show that CD177⁺ neutrophil–platelet aggregates promote neutrophil extracellular trap (NET)-linked thromboinflammation in NEC and that blocking CD177/NET formation or low-molecular-weight heparin alleviates disease in mouse models.

This work presents a quantum-cutting heterostructure that emits tunable near-infrared light (900-2200 nm) under ultralow-power excitation. It enables AI-assisted multiplexed gas detection, offering a scalable strategy for broadband NIR light sources

Reversible proton ceramic electrochemical cells enable efficient power generation and green H₂ production. Here, the authors report a multi-element micro-doped perovskite oxygen electrode inducing ionic disorder to enhance oxygen-water reaction activity.

While previous studies of Kondo physics have largely focused on electronic properties, the authors here investigate magnon damping in the d-electron van der Waals magnet Fe₃GeTe₂. They observe logarithmic scaling of the damping at low temperatures and a minimum at an intermediate temperature, which they attribute to Kondo coupling between itinerant electrons and local moments.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Gastric perforation sealing is challenging due to the acidic environment presented by gastric fluid. Here, authors report an injectable hydrogel bioadhesive for sealing of large gastric perforations.

Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8⁺ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.

Water and oxygen jointly influence the oxidation of copper, but their respective roles are difficult to disentangle. Here, the authors show that hydroxyl species adsorb at the Cu/CuO_x interface, roughen the surface, and enable deeper oxygen penetration and higher Cu mobility.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

Sodium-ion batteries require electrolytes that withstand high voltages and low temperatures for commercial use. Here, authors design a non-flammable sulfonamide solvent with a melting point as low as −86 °C, enabling stable, conductive interphases on both electrodes. This electrolyte allows 1-Ah pouch cells to retain capacity at −60 °C/−70 °C and achieve long cycling stability (up to 81.6% after 1000 cycles at 4.2 V).

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

Selenization is a key step in kesterite solar cell fabrication, but controlling ion migration during this process is challenging. Cui et al. address this issue by introducing a Li₂SnS₃ interphase, achieving a certified power conversion efficiency of 15.0%.

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

In this work the authors employed deep learning-based methods to design mini-protein that block membrane insertion of complement C9. These well performed inhibitors provide an alternative approach for preventing diseases associated with abnormal complement activation.

Top-down trophic interactions are critical drivers of microbiome dynamics but are difficult to predict. Here, the authors demonstrate that nematode-driven shifts in microbiomes enhance pathogen suppression and promote plant health through a feedback loop involving nematodes and bacteria.

This cohort study demonstrates that the risk of stroke negatively associates with the level of intrinsic capacity. Notably, among adults aged 80 years and above, higher intrinsic capacity is significantly linked to a lower incidence of stroke.

The thermoelectric performance of rhombohedral GeTe-based material is boosted by the TiB₂ nanoparticle-induced interfacial constraint effect that results in reduced equivalent deformation potential and substantial interfacial thermal resistance.