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Showing 1–50 of 74 results

Advanced filters: Author: Wei Lun Ng Clear advanced filters

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

Zhao-Jun Pan
Wei-Lun Wei
Shih-Shun Lin
ResearchOpen Access13 Mar 2025
Nature Communications

Volume: 16, P: 1-18
Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation

Han Wu
Wei-tao Jiang
Yu Bian
ResearchOpen Access19 Jan 2026
Acta Pharmacologica Sinica

P: 1-14
Diffusing protein binders to intrinsically disordered proteins

Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.

Caixuan Liu
Kejia Wu
David Baker
ResearchOpen Access30 Jul 2025
Nature

Volume: 644, P: 809-817
Structure and mechanism of the mitochondrial calcium transporter NCLX

Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H⁺/Ca²⁺ rather than a Na⁺/Ca²⁺ exchanger, and uncover its transport mechanism with implications for therapies treating cardiac and neurodegenerative disorders related to abnormal mitochondrial Ca²⁺.

Minrui Fan
Chen-Wei Tsai
Liang Feng
ResearchOpen Access10 Sept 2025
Nature

Volume: 646, P: 1272-1280
Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis

Zhang and colleagues use single-cell RNA sequencing on the nasal mucosa to identify cell subsets and molecules that specifically contribute to the pathogenesis of chronic rhinosinusitis subtypes.

Weiqing Wang
Yi Xu
Jianmin Zhang
Research22 Sept 2022
Nature Immunology

Volume: 23, P: 1484-1494
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization

Tumor microenvironment varies between primary and metastatic sites. Here they report tumor-associated macrophages from metastatic sites to be predominantly M2 type, and secrete IL-35 to promote metastasis through activation of JAK2–STAT6–GATA3 signaling.

Chih-Chan Lee
Jiunn-Chang Lin
Muh-Hwa Yang
ResearchOpen Access14 Sept 2018
Nature Communications

Volume: 9, P: 1-18
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.

Heng-Huan Lee
Ying-Nai Wang
Mien-Chie Hung
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-18
Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA

Cao and colleagues identify the E3 ubiquitin ligase RNF2 as an inhibitor of interferon-dependent antiviral responses that acts by promoting the K33-linked polyubiquitination of STAT1 and its disassociation from DNA.

Shuo Liu
Minghong Jiang
Xuetao Cao
Research21 Nov 2017
Nature Immunology

Volume: 19, P: 41-52
A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators

A common East Asian-specific defect of an alcohol metabolizing enzyme (ALDH2) causes glucose abnormality, obesity, and fatty liver. Here, the authors show an ALDH2 activator can treat these metabolic disorders in mice.

Yi-Cheng Chang
Hsiao-Lin Lee
Lee-Ming Chuang
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-16
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells

Wang, Yang and colleagues delineate a Snail-β-catenin-miR-146a signalling axis that directs a switch from asymmetric to symmetric cell division, resulting in colorectal cancer stem cell expansion.

Wei-Lun Hwang
Jeng-Kae Jiang
Muh-Hwa Yang
Research23 Feb 2014
Nature Cell Biology

Volume: 16, P: 268-280
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation

Jia-Wei Zhou
Ying Bai
Dong Hu
ResearchOpen Access24 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-19
Identification of apelin/APJ signaling dysregulation in a human iPSC-derived granulosa cell model of Turner syndrome

Wei-Ju Chen
Yi-Ya Chao
Jean Lu
ResearchOpen Access14 Nov 2024
Cell Death Discovery

Volume: 10, P: 1-14
Cholesterol efflux from C1QB-expressing macrophages is associated with resistance to chimeric antigen receptor T cell therapy in primary refractory diffuse large B cell lymphoma

Although the efficacy of chimaeric antigen receptor (CAR) T cell therapy has been demonstrated in relapsed/refractory diffuse large B-cell lymphoma (DLBCL), it has not been investigated in primary refractory DLBCL. In this phase I clinical trial, the authors report on the safety and efficacy of relmacabtagene autoleucel, a CD19-specific CAR T cell product, and demonstrate using single-cell RNA sequencing that cholesterol efflux from macrophages may impair CAR T cell responses in this context.

Zi-Xun Yan
Yan Dong
Wei-Li Zhao
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-16
Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy

Here the authors report on exoelectrogenic bacteria-derived membrane fusion-liposome-coated titanium dioxide nanoparticles to mimic extracellular electron transfer to enhance superoxide anion production under low-dose X-ray irradiation for radiodynamic therapy.

Ying-Chi Chen
Yi-Ting Li
Chen-Sheng Yeh
Research03 Aug 2023
Nature Nanotechnology

Volume: 18, P: 1492-1501
Glial growth factor 2 treatment alleviates ischemia and reperfusion-damaged integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and Pdlim5/YAP/TAZ-mediated paracellular permeability

Xiao-ling Zhang
Wei-hong Du
Xin-chun Jin
Research20 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2241-2252
High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation

High-salt intake can promote pro-inflammatory responses associated with pathological conditions. However, here, the authors show that high-salt diet may have an antitumor protective role by modulating the accumulation and phenotype of myeloid derived suppressor cells and enhancing immunosurveillance.

Wei He
Jinzhi Xu
Lei Dong
ResearchOpen Access07 Apr 2020
Nature Communications

Volume: 11, P: 1-17
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

Li Yu
Chunhui Liu
Christoph Plass
Research20 Feb 2005
Nature Genetics

Volume: 37, P: 265-274
Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

Adjuvant gefitinib improves outcomes in non-small cell lung cancer (NSCLC) patients compared to chemotherapy, but not in all cases. Here, the authors find genomic biomarkers of response to gefitinib in NSCLC patients from the ADJUVANT trial, and propose a score to stratify them by potential benefit from the treatment.

Si-Yang Liu
Hua Bao
Yi-Long Wu
ResearchOpen Access08 Nov 2021
Nature Communications

Volume: 12, P: 1-11
Nicotinamide phosphoribosyltransferase as a biomarker for the diagnosis of infectious pleural effusions

Jing Huang
Lun Guo
Qun-Li Ding
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-9
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

Long Yu and colleagues report a genome-wide association study for hepatitis B virus–related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC.

De-Ke Jiang
Jielin Sun
Long Yu
Research16 Dec 2012
Nature Genetics

Volume: 45, P: 72-75
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

George Vassiliou, Allan Bradley and colleagues perform a Sleeping Beauty transposon mutagenesis screen to identify insertions that cooperate with mutant Npm1 to produce acute myeloid leukemia (AML) in mice. They observed mutually exclusive integrations in Csf2, Flt3 or Rasgrp1 in a high percentage of cases, providing insights into the molecular pathogenesis of this AML subtype.

George S Vassiliou
Jonathan L Cooper
Allan Bradley
Research27 Mar 2011
Nature Genetics

Volume: 43, P: 470-475
The tissue specific regulation of miR22 expression in the lung and brain by ribosomal protein L29

Mohammad Ishaque Ali
Linrui Li
Guoquan Liu
ResearchOpen Access01 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
A genome-wide association study for melatonin secretion

Pi-Hua Liu
Gwo-Tsann Chuang
Yi-Cheng Chang
ResearchOpen Access16 May 2022
Scientific Reports

Volume: 12, P: 1-8
The draft genome of sweet orange (Citrus sinensis)

Yijun Ruan and colleagues report the draft genome of the sweet orange, Citrus sinensis. Their data suggests sweet orange originated from a cross between pummelo and mandarin.

Qiang Xu
Ling-Ling Chen
Yijun Ruan
ResearchOpen Access25 Nov 2012
Nature Genetics

Volume: 45, P: 59-66
Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties

Adeno-associated viruses (AAVs) are vehicles for gene therapy in humans, but currently only a limited amount of AAV serotypes is available. Here, the authors identify a novel AAV, AAVv66, and demonstrate enhanced production yields, virion stability, and CNS transduction compared to the clinically approved serotype AAV2.

Hung-Lun Hsu
Alexander Brown
Guangping Gao
ResearchOpen Access30 Jun 2020
Nature Communications

Volume: 11, P: 1-14
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming

Triple-negative breast cancer is an aggressive form of the disease. Here, the authors identify EGFL9 as a mediator of metastasis in TNBC through interactions with cMET.

Fanyan Meng
Ling Wu
Guojun Wu
ResearchOpen Access06 Nov 2019
Nature Communications

Volume: 10, P: 1-17
A genome-wide association study identifies two new risk loci for Graves' disease

Huai-Dong Song and colleagues report results of a genome-wide association study of Graves' disease. They confirm four previously reported risk loci for this disease and identify two new susceptibility loci at 4p14 and 6q27.

Xun Chu
Chun-Ming Pan
Huai-Dong Song
Research14 Aug 2011
Nature Genetics

Volume: 43, P: 897-901
Analysis of the 1-year efficacy of four different surgical methods for treating Chinese super obese (BMI ≥ 50 kg/m²) patients

Zheng Zhang
Lun Wang
Tao Jiang
ResearchOpen Access07 May 2024
Scientific Reports

Volume: 14, P: 1-8
Heat stress response in the cave nectar bat Eonycteris spelaea differs from that of Mus musculus

A re-wired heat shock response in the Cave nectar bat, Eonycteris spelaea, is associated with enhanced physiological heat resistance.

Leon J. W. Tang
Akshamal M. Gamage
Lin-Fa Wang
ResearchOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1-15
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.

Ying Cheng
Zhi-Meng Wang
Peng Jin
Research05 Nov 2018
Nature Neuroscience

Volume: 21, P: 1689-1703
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.

Fan Wang
Cheng-Qi Xu
Qing K Wang
Research06 Mar 2011
Nature Genetics

Volume: 43, P: 345-349
A reporter mouse for non-invasive detection of toll-like receptor ligands induced acute phase responses

Chun-Fang Huang
Shang-Yi Chiu
Yu-Chia Su
ResearchOpen Access13 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Evolution of coastal forests based on a full set of mangrove genomes

Analysis of 48 newly generated genomes, including 32 mangrove species, sheds light on patterns of speciation and extinction of these woody, coastal plants.

Ziwen He
Xiao Feng
Suhua Shi
Research28 Apr 2022
Nature Ecology & Evolution

Volume: 6, P: 738-749
The prognostic value of N-terminal proB-type natriuretic peptide in patients with acute respiratory distress syndrome

Chih-Cheng Lai
Mei-I. Sung
Kuo-Chen Cheng
ResearchOpen Access21 Mar 2017
Scientific Reports

Volume: 7, P: 1-6
Comparison of senhance and da vinci robotic radical prostatectomy: short-term outcomes, learning curve, and cost analysis

Yen-Chun Lin
Lun-Hsiang Yuan
Shi-Wei Huang
Research02 Sept 2023
Prostate Cancer and Prostatic Diseases

Volume: 27, P: 116-121
FBXW7 is a multifaceted regulator of the innate immune response to DNA viruses

Xue-Dan Sun
Jia-Li Wang
Ming-Ming Hu
Research08 Sept 2025
Cellular & Molecular Immunology

Volume: 22, P: 1427-1443
Exposure to tobacco smoke and childhood rhinitis: a population-based study

Tsung-Chieh Yao
Su-Wei Chang
Jing-Long Huang
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition

Lifu Hu
Lun Wang
Tao Jiang
ResearchOpen Access19 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
A cell-based screening system for anti-influenza A virus agents

Wan Ying Wong
Sheng Wei Loh
Chee-Kwee Ea
ResearchOpen Access02 Mar 2015
Scientific Reports

Volume: 5, P: 1-7
Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant

Shen-Yang Lim
Tzi Shin Toh
Ai Huey Tan
ResearchOpen Access23 Feb 2025
npj Parkinson's Disease

Volume: 11, P: 1-9
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl⁻ accumulation in respiratory epithelium

Lei Chen
Wei-Jie Guan
Yi-Lin Zhang
ResearchOpen Access27 Jul 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway

Wei Lun Ng
Georgi K. Marinov
Chee-Kwee Ea
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-7
Genome-wide association study for circulating fibroblast growth factor 21 and 23

Gwo-Tsann Chuang
Pi-Hua Liu
Yi-Cheng Chang
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-12
Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model

Xiao-ying Sun
Xiao-lin Yu
Rui-tian Liu
ResearchOpen Access25 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice

Yun-Hsiang Chen
Kuo-Jen Wu
Yun Wang
ResearchOpen Access07 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene

Ke-En Tan
Wei Lun Ng
Yat-Yuen Lim
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-15
Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Zhi-lun Yu
Rui-yang Gao
Wei Dou
ResearchOpen Access15 Mar 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1451-1465
LncRNA HOTAIR regulates autophagy and proliferation mechanisms in premature ovarian insufficiency through the miR-148b-3p/ATG14 axis

Chao Luo
Lun Wei
Caiping Mao
ResearchOpen Access24 Jan 2024
Cell Death Discovery

Volume: 10, P: 1-11
NRG1 regulates Fra-1 transcription and metastasis of triple-negative breast cancer cells via the c-Myc ubiquitination as manipulated by ERK1/2-mediated Fbxw7 phosphorylation

Le Shu
Ao Chen
Guoquan Liu
Research07 Jan 2022
Oncogene

Volume: 41, P: 907-919

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