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Single-cell multi-omics integration across gene expression, protein abundance and chromatin accessibility remains challenging. The authors present scMAGCA, an interpretable framework for integrating these modalities, and apply it to Alzheimer’s disease and kidney cancer to identify disease-associated cell states and biomarkers.

Reversible-deactivation radical polymerisations are highly sensitive to oxygen and inhibitors, hindering their industrial application. Here, the authors report a heterogeneous phenanthroline-based conjugated hypercrosslinked polymer photocatalyst for photoinduced copper-catalysed atom transfer radical polymerisations, achieving high oxygen and inhibitor tolerance.

Mucosal melanoma is a rare and aggressive subtype which, unlike cutaneous melanoma, shows limited response to immune checkpoint inhibition. Here, the authors report the safety and efficacy of neoadjuvant pembrolizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibition) in patients with resectable mucosal melanoma, along with exploratory biomarker analysis.

Spatial transcriptomics platforms span multicellular to subcellular resolutions but lack methods to reconstruct single-cell transcriptomes across them. Here, the authors introduce STARS, a unified deep learning framework that integrates histology and transcriptomics to infer single-cell gene expression across resolutions.

Organic afterglow mechanisms remain debated in carbazole-based analog-doped materials. The authors show afterglow is dominated by guest phosphorescence from deep triplet traps, while carrier traps contribute only weak long-persistent luminescence.

How co-invading species facilitate one another remains largely unknown. This study shows that facilitation is often asymmetric and increases when co-invading plants differ in competitiveness and their ability to shape microbial communities.

The authors report ambient-pressure, polarization-resolved electronic Raman scattering measurements on single crystals of nickelate La₃Ni₂O₇, which becomes superconducting under pressure. Quantitative analysis reveals momentum-selective spin density wave (SDW) gap amplitudes, indicating an unconventional SDW driven by anisotropic electronic correlations.

Why hollow porous crystals speed reactions has remained unclear. Real-time imaging in a model metal organic framework shows that hollow particles separate products from reactants, and shell thickness controls this transport and catalytic gain.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Using warming microcosms across 100 paired sites, a global meta-analysis and microbiome manipulation experiments, this study shows that agricultural microbiomes confer higher compositional and multifunctionality resistance to warming and can transfer this resistance to natural soils.

Mitochondrial cristae structure is essential for energy production and immune regulation, but therapeutic strategies targeting cristae remodeling are lacking. Here, the authors show that targeting triose phosphate isomerase 1 restores cristae architecture, rewires microglial metabolism, and protects against ischemic stroke.

Skin lesions are common manifestations of systemic lupus erythematosus (SLE). Here, the authors present a spatial transcriptomic atlas of lesional skin from patients with lupus and identify an acute inflammatory signature in SLE, contrasting with chronic damage in tertiary lymphoid structures in discoid lupus.

Artificial intelligence is increasingly used in medical imaging, but its realworld clinical value for report generation is unclear. Here, the authors show that AI assistance in chest X-ray interpretation reduced reading time while maintaining diagnostic accuracy and agreement in a prospective study.

Dead metal severely inhibited the development of alkali metal batteries. Here, authors reactivated dead Na by a reverse-pulse-interspersed charging strategy, which enhanced the rate and cycle capabilities of anode-free battery, and showed wide applicability to various alkali metal batteries.

The high demand of soft strain sensors requires solutions to reduce resource waste. Here, the authors propose a machine learning framework that corrects unstable signals in soft strain sensors, making them more accurate, reliable and longer-lasting, and extending their usable lifetime by more than 3,000 times.

Tracing the origins of lithium dendrite growth remains a critical challenge for lithium metal batteries. Here, the authors introduce an interfacial excess charge distribution factor to understand lithium dendrite growth, guiding the design of an electrolyte that suppresses Li dendrites in practical pouch cells.

Chronic diseases often need long-acting formulations to improve patient adherence. Here, the authors report a surface-erodible polyketal–tafluprost microparticle formulation that enables extended drug release, prolonged intraocular pressure reduction following a single subconjunctival injection, with good ocular biocompatibility, and enhanced efficacy verified in ocular hypertensive female rats.

The authors conducted two trials to evaluate the efficacy and safety of NH600001, an etomidate derivative, in gastrointestinal endoscopy. The results showed NH600001 has a sedative effect while reducing the risk of adrenocortical depression.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

Neuraminidase activity of NEU1 regulates insulin resistance and glucose tolerance. Here the authors report that NEU1 also inhibits hepatic gluconeogenesis in a non-enzymatic manner by binding SAM68, thereby activating GCN5 transcription.

Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.

Stretchable conductors are crucial for next-generation wearable electronics, though many systems using liquid metal conductors have unfavourable mechanical properties. Here the authors report a method embedding liquid metal particles into a hydrogel network to optimize conductive and mechanical properties for soft robots.

CNS injury disrupts neural circuits, with poor regeneration due to HDAC retention and hostile environments. Here, the authors show a nanosystem with LMK-235 that forms electroactive scaffolds and promotes regeneration and enhances synaptic reconnection

The success of KRAS G12C mutation specific inhibitors in patients with KRAS-driven tumours is limited by the emergence of acquired resistance. Here, the authors characterise olomorasib, a next-generation covalent KRAS G12C-mutant inhibitor, demonstrating efficacy in the presence of clinically relevant resistance mutations in preclinical KRAS-driven cancer models.

The unclear pathogenesis of cancer-related lymphedema (CRL) impedes therapeutic development. The authors here identify T-cell mesenchymal transition (TcMT) in CRL, where T cells acquire a fibrotic phenotype, offering a potential therapeutic target.

Stabilizing metal oxides is a prerequisite for efficient electrochemical CO2 reduction. Here, the authors report a La2O3-socketed δ-Bi2O3 heterojunction that impedes Bi2O3 reduction to metallic Bi, achieving high-efficiency formate production in industrial-level electrolyzers.

Electric-field-controllable, stochastic alteration of multiple conductance states in a Sc₂C₂@C₈₈ cluster is observed. A matrix-chain multiplication of two 4 × 4 state-transition matrices is demonstrated using this cluster with maximum error of less than 0.05.

By introducing local ferroelectric regions into a high-entropy superparaelectric, researchers develop a design strategy for high-performance energy storage ceramics. They incorporate ferroelectric PbTiO₃ into a high-entropy matrix, achieving a high recoverable energy density.

This study elucidates the regulatory function of the PcabHLH58/PcabHLH151- PcaSCL33/PcaPLT1-WOX5 module in poplar adventitious root development and nitrogen uptake, while PcaPAR1 forms a feedback regulatory loop with PcabHLH58/PcabHLH151.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

UCl₃-type electrolytes show promise for all-solid-state batteries, yet their structure and Li⁺ transport remain debated. Here, authors reveal foreign cations reside in the amorphous phase, which serve as the dominant Li⁺ pathway yielding enhanced conductivity and low-temperature battery performance.

Sorbic acid is a widely used food preservative, yet its industrial production lacks a sustainable microbial route. Here the authors identify the biosynthetic pathway of sorbic acid and engineer yeast for its efficient production.

The study uncovers CBP/p300 as regulators of functional α cell mass via orchestrating Slc7a2/lysine-driven α cell identity gene.

Wang et al. report dual cationic imidazole ligands to control perovskite dimensionality, from 0D to parallel 1D, and bridged 1D structures. Bridged 1D/3D perovskite heterostructure enables solar cells with certified efficiency of 27.02% and 30×30 cm² solar modules with efficiency of 21.41%.

The substantial overlap in symptoms and pathology between musculoskeletal disorders suggests the need to investigate their shared genetic mechanisms. Here the authors use multivariate genetic modelling to identify three distinct pathological factors across these diseases, providing insights into co-prevention and co-management strategies.

The authors report a polymer-templating strategy that accelerates perovskite nucleation through weak, reversible interactions, enables the growth of large single crystals, and offers a broadly applicable route to controlled crystallisation across halide perovskites.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

In a multicentre trial of AAV1-hOTOF gene therapy involving 42 participants aged 0.8–32.3 years with autosomal recessive deafness 9, treatment demonstrated safety, tolerability, and improved hearing and speech perception, with age and distortion product otoacoustic emissions associated with treatment outcomes.

Researchers show that additive manufacturing can create high-density stable edge dislocations in a refractory high-entropy alloy, enabling unusually strong yet ductile performance at high temperatures and providing a new route to extreme-environment materials.

The ferromagnetic cobalt-based catalyst with fully exposed strained Co(111) lattice plane boosts peracetic acid utilization under a mild magnetic field, producing plenty of reactive species for pollutant abatement and greener water remediations.

Cell-type-specific 3D genome maps are hard to generate experimentally. Here, the authors develop Hi-Compass, a deep-learning framework that predicts chromatin interactions from accessibility data across variable sequencing depths, recovering chromatin loops and linking disease variants to target genes.

Understanding the subcellular distribution of RNA-binding proteins can shed light on their structural and functional features. Here, the authors map RNA-binding proteins across cellular compartments, revealing hierarchies and atypical functions.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.