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Showing 1–2 of 2 results
Advanced filters: Author: Weihui Ou Clear advanced filters

  • Cyclic di-GMP (c-di-GMP) is a second messenger that promotes biofilm formation through unclear mechanisms in several bacterial species. Here, Ling et al. report that c-di-GMP promotes biofilm formation in mycobacteria by binding to protein Lsr2, which upregulates the synthesis of keto-mycolic acid and thus biofilm formation.

    • Xiaocui Ling
    • Xiao Liu
    • Weihui Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Conventional photo-driven cancer treatment agents require oxygen and visible light to induce cell death, limiting their efficacy in deep, oxygen-poor tumours. Now, a class of NIR-activatable Pt(IV) photooxidants that target the endoplasmic reticulum have been shown to effectively overcome these limitations by directly oxidizing intracellular biomolecules in an oxygen-independent fashion, presenting a promising new direction for next-generation metal-based drug development.

    • Zhiqin Deng
    • Huangcan Li
    • Guangyu Zhu
    Research
    Nature Chemistry
    Volume: 15, P: 930-939