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TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia

DNA demethylation enzyme TET1 is a known oncogene in leukemia. Here, the authors discover that TET1 is involved in GPX4-dependent and -independent ferroptosis in acute myeloid leukemia via the regulation of GSH synthesis enzyme GCLC and BH4 synthesis enzyme GCH1.

Lingling Yang
Jun Lu
Xi Jiang
ResearchOpen Access20 Jan 2026
Nature Communications

Volume: 17, P: 1-17
Author Correction: Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

Ting Li
Dingyi Lu
Xin Pan
Amendments and CorrectionsOpen Access17 Mar 2022
Nature Communications

Volume: 13, P: 1
Bioinspired artificial spider silk photocatalyst for the high-efficiency capture and inactivation of bacteria aerosols

Bioaerosol can cause the spread of disease, but current removal systems are easily blocked and often cannot deactivate the bioaerosol. Here, the authors report a method for bioaerosol removal and deactivation using a bioinspired photocatalyst capable of capturing airborne bacteria.

Linghui Peng
Haiyu Wang
Taicheng An
ResearchOpen Access27 Apr 2023
Nature Communications

Volume: 14, P: 1-11
Heterogeneity of late-infantile neuronal ceroid lipofuscinosis

Nanbert Zhong
Dorota N Moroziewicz
W Ted Brown
Research01 Nov 2000
Genetics in Medicine

Volume: 2, P: 312-318
Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

Here the authors show that the Koolen-de Vries syndrome associated gene KANSL1 modulates autophagosome-lysosome fusion via transcriptional regulation of autophagosomal gene Syntaxin17, and that 13-cis retinoic acid can reverses mitophagic defects and neurobehavioural abnormalities of mice lacking Kansl1.

Ting Li
Dingyi Lu
Xin Pan
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-16
CRISPR/Cas9 library screening uncovered CCT2 as a critical driver of acquired resistance to EGFR-targeted therapy by stabilizing TMX1 in non-small cell lung cancer

Zihao Ke
Qi Zhang
Chao Cao
Research30 Oct 2025
Cell Death & Differentiation

Volume: 33, P: 860-876
Regulating the spatial distribution of metal nanoparticles within metal-organic frameworks to enhance catalytic efficiency

Composites incorporating metallic nanoparticles into metal-organic frameworks are potentially useful but controlling the nanoparticle spatial distribution is challenging. Here, the authors report a strategy that accomplishes this by using a metal oxide as both support and sacrificial template.

Qiu Yang
Wenxian Liu
Jun Lu
ResearchOpen Access14 Feb 2017
Nature Communications

Volume: 8, P: 1-9
Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

In leukemic mice, fasting reduces the development of acute lymphoblastic leukemia, but not acute myeloid leukemia, via upregulation of leptin receptor expression and signaling in the leukemic cells.

Zhigang Lu
Jingjing Xie
Cheng Cheng Zhang
Research12 Dec 2016
Nature Medicine

Volume: 23, P: 79-90
Graphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux

Implementing enzymatic reactions in gas phase has several limitations. Here, the authors report on a method to overcome these using graphene oxide aerogels to immobilize lipase, improve stability/lifetime and investigate the mechanism for improved function.

Weina Xu
Zhongwang Fu
Zheng Liu
ResearchOpen Access18 Jun 2019
Nature Communications

Volume: 10, P: 1-8
Detection of influenza A virus from live-bird market poultry swab samples in China by a pan-IAV, one-step reverse-transcription FRET-PCR

Lu Luan
Zhihao Sun
Chengming Wang
ResearchOpen Access22 Jul 2016
Scientific Reports

Volume: 6, P: 1-9
Conjoint and dissociated structural and functional abnormalities in first-episode drug-naive patients with major depressive disorder: a multimodal meta-analysis

Weina Wang
Youjin Zhao
Qiyong Gong
ResearchOpen Access04 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and support the infiltration of tumour cells into tissues.

Mi Deng
Xun Gui
Cheng Cheng Zhang
Research17 Oct 2018
Nature

Volume: 562, P: 605-609
NAD⁺-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

NAD⁺ deficiency impairing Sirt6 function reveals the mechanism of in vitro culture-induced telomere shortening in preimplantation embryos, providing a target to improve IVF outcomes.

Danjun Li
Wenzhi Li
Qifeng Lyu
ResearchOpen Access23 Aug 2025
Communications Biology

Volume: 8, P: 1-15
Codon-optimized FAM132b gene therapy prevents dietary obesity by blockading adrenergic response and insulin action

Zhengtang Qi
Jie Xia
Weina Liu
Research03 Aug 2022
International Journal of Obesity

Volume: 46, P: 1970-1982
Elastic, Conductive, Polymeric Hydrogels and Sponges

Yun Lu
Weina He
Xuetong Zhang
ResearchOpen Access23 Jul 2014
Scientific Reports

Volume: 4, P: 1-8
TGF-β signaling promotes eosinophil activation in inflammatory responses

Chen Zhu
Qingyu Weng
Wen Li
ResearchOpen Access30 Aug 2024
Cell Death & Disease

Volume: 15, P: 1-10
FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes

Lu Gan
Zhenjiang Liu
Chao Sun
ResearchOpen Access27 Aug 2015
Scientific Reports

Volume: 5, P: 1-12
Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin

Rong Du
Xi Cheng
Yuquan Zhang
ResearchOpen Access17 Mar 2023
Scientific Reports

Volume: 13, P: 1-16
Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes

Zhenjiang Liu
Lu Gan
Chao Sun
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Association of dietary patterns with the newly diagnosed diabetes mellitus and central obesity: a community based cross-sectional study

Xueyao Yin
Yixin Chen
Lin LI
ResearchOpen Access04 Jun 2020
Nutrition & Diabetes

Volume: 10, P: 1-9
To Be a Flower or Fruiting Branch: Insights Revealed by mRNA and Small RNA Transcriptomes from Different Cotton Developmental Stages

Quan Sun
Xiongming Du
Yingfan Cai
ResearchOpen Access17 Mar 2016
Scientific Reports

Volume: 6, P: 1-19
Controllable Plasmonic Nanostructures induced by Dual-wavelength Femtosecond Laser Irradiation

Weina Han
Lan Jiang
Yongfeng Lu
ResearchOpen Access11 Dec 2017
Scientific Reports

Volume: 7, P: 1-11
Genetics and pathologic landscape of lineage switch of acute leukemia during therapy

Ting Zhou
Choladda V. Curry
Shimin Hu
CorrespondenceOpen Access25 Jan 2024
Blood Cancer Journal

Volume: 14, P: 1-6

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TET1 as a master regulator controlling GPX4-dependent and -independent ferroptosis surveillance in acute myeloid leukemia

Author Correction: Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

Bioinspired artificial spider silk photocatalyst for the high-efficiency capture and inactivation of bacteria aerosols

Heterogeneity of late-infantile neuronal ceroid lipofuscinosis

Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice

CRISPR/Cas9 library screening uncovered CCT2 as a critical driver of acquired resistance to EGFR-targeted therapy by stabilizing TMX1 in non-small cell lung cancer

Regulating the spatial distribution of metal nanoparticles within metal-organic frameworks to enhance catalytic efficiency

Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation

Graphene oxide enabled long-term enzymatic transesterification in an anhydrous gas flux

Detection of influenza A virus from live-bird market poultry swab samples in China by a pan-IAV, one-step reverse-transcription FRET-PCR

Conjoint and dissociated structural and functional abnormalities in first-episode drug-naive patients with major depressive disorder: a multimodal meta-analysis

LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration

NAD⁺-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos

Codon-optimized FAM132b gene therapy prevents dietary obesity by blockading adrenergic response and insulin action

Elastic, Conductive, Polymeric Hydrogels and Sponges

TGF-β signaling promotes eosinophil activation in inflammatory responses

FABP4 reversed the regulation of leptin on mitochondrial fatty acid oxidation in mice adipocytes

Mechanism of ferroptosis in a rat model of premature ovarian insufficiency induced by cisplatin

Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes

Association of dietary patterns with the newly diagnosed diabetes mellitus and central obesity: a community based cross-sectional study

To Be a Flower or Fruiting Branch: Insights Revealed by mRNA and Small RNA Transcriptomes from Different Cotton Developmental Stages

Controllable Plasmonic Nanostructures induced by Dual-wavelength Femtosecond Laser Irradiation

Genetics and pathologic landscape of lineage switch of acute leukemia during therapy

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