Nature Search

Knowledge-guided adaptation of pathology foundation models effectively improves cross-domain generalization and demographic fairness

Pathology foundation models can still struggle with generalizability and fairness across demographic groups. Here, the authors develop FLEX, a framework to enhance cross-domain generalization and demographic fairness in pathology foundation models, improving performance and mitigating disparities in cancer datasets.

Yanyan Huang
Weiqin Zhao
Lequan Yu
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axis

Erythropoietin (EPO) regulates energy metabolism via its receptor (EpoR) in adipose tissue. The authors demonstrate that EPO influences glucose tolerance, insulin sensitivity, and fat mass and that EPO treatment reduces lipogenic gene expression through the EPO-EpoR-RUNX1 axis.

Weiqin Yin
Praveen Kumar Rajvanshi
Constance T. Noguchi
ResearchOpen Access16 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems

Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six continents, providing insights into biotic and abiotic mechanisms that appear to control ARG diversity and distribution.

Congmin Zhu
Linwei Wu
Jizhong Zhou
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Joint association of overweight/obesity, high electronic screen time, and low physical activity time with early pubertal development in girls: a case–control study

Weiqin Li
Lingyan Feng
Junhong Leng
ResearchOpen Access08 May 2024
Scientific Reports

Volume: 14, P: 1-9
Development of a novel model of hypertriglyceridemic acute pancreatitis in mice

Yiyuan Pan
Yong Li
Jieshou Li
ResearchOpen Access12 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Initial trajectory design of low-thrust spacecraft considering attitude constraints

Zichen Fan
Weiqin Ke
Shaobiao Xie
ResearchOpen Access30 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Seasonal variation and its interaction with pre-pregnancy BMI for GDM: a large population-based study in Tianjin, China

Weiqin Li
Leishen Wang
Junhong Leng
ResearchOpen Access21 Dec 2023
Scientific Reports

Volume: 13, P: 1-8
Subsurface oxygen defects electronically interacting with active sites on In₂O₃ for enhanced photothermocatalytic CO₂ reduction

How to effectively extract electrons from subsurface oxygen defects is challenging in heterogeneous catalysis. Here the authors demonstrate that Metallic In-embedded In2O3 nanoflake catalyst promotes the delocalization of electrons among subsurface oxygen defects, obviously increasing electron density of surface active sites.

Weiqin Wei
Zhen Wei
Hong Yuan
ResearchOpen Access09 Jun 2022
Nature Communications

Volume: 13, P: 1-12
ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation

Yuan Tian
Bin Yang
Pengyuan Yang
ResearchOpen Access29 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Three-Dimensional Physical Model-Assisted Planning and Navigation for Laparoscopic Partial Nephrectomy in Patients with Endophytic Renal Tumors

Gang Fan
Jun Li
Yu Xie
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-6
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.

Hanyong Sun
Weiqin Yang
Alfred S. L. Cheng
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-16
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics

Zhiheng Rao
Zhichao Chen
Yongde Luo
ResearchOpen Access26 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-25
Prevalence of hyperuricemia and its related risk factors among preschool children from China

Nan Li
Shuang Zhang
Junhong Leng
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
Early Spontaneous Abdominal Bleeding is associated with Poor Outcome in Moderate to Severe Acute Pancreatitis Patients: A Propensity Matched Study

Yizhe Chen
Jing Zhou
Jieshou Li
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-8
Ammonia-oxidizing bacteria and archaea exhibit differential nitrogen source preferences

Isotope tracing, kinetics and transcriptomics show how members of the four AOM lineages employ different nitrogen use strategies that minimize competition for nitrogen substrates.

Wei Qin
Stephany P. Wei
Mari-Karoliina H. Winkler
Research31 Jan 2024
Nature Microbiology

Volume: 9, P: 524-536
Facile synthesis of the Ti³⁺ self-doped TiO₂-graphene nanosheet composites with enhanced photocatalysis

Bocheng Qiu
Yi Zhou
Jinlong Zhang
ResearchOpen Access26 Feb 2015
Scientific Reports

Volume: 5, P: 1-6
Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

Yunan Wang
Abudurexiti Kayoumu
George Liu
ResearchOpen Access15 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
The MC4R genotype is associated with postpartum weight reduction and glycemic changes among women with prior gestational diabetes: longitudinal analysis

Aline Martins de Carvalho
Ping Shao
Lu Qi
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Influencing factor analysis and clinical efficacy of early intervention in severe acute pancreatitis with persistent organ failure

Minchun Bu
Yun Zhang
Weiqin Li
ResearchOpen Access09 May 2025
Scientific Reports

Volume: 15, P: 1-10
Towards biomarker-driven cancer immunotherapy: the rising of a protein phosphatase regulator

Xiaoyu Liu
Weiqin Yang
Alfred Sze-Lok Cheng
Research HighlightsOpen Access14 Oct 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-3
Landscapes of immunoglobulin heavy-chain gene repertoire and its cytogenetic abnormalities in Chinese patients with multiple myeloma

Yanlei Gong
Tingting Tao
Li Yao
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Tao Zhang
Weiqin Zhang
Zhihong Sun
ResearchOpen Access15 Nov 2022
npj Science of Food

Volume: 6, P: 1-10
Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis

Muyun Liu
Dan Wang
Weiqin Lu
ResearchOpen Access16 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-15
Growth changes of tomato seedlings responding to sodium salt of α-naphthalene acetic acid and potassium salt of fulvic acid

Maofei Ren
Guiling Mao
Qiyuan Tang
ResearchOpen Access10 Mar 2023
Scientific Reports

Volume: 13, P: 1-11
Early gestational weight gain and birth weight outcome: a Chinese population-based cohort

Shuang Zhang
Lingyan Feng
Huikun Liu
ResearchOpen Access19 Aug 2025
Pediatric Research

P: 1-7
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver

Wenshu Tang
Jingying Zhou
Alfred S. L. Cheng
Research20 May 2022
Cellular & Molecular Immunology

Volume: 19, P: 834-847
Association of energy delivery with short-term survival in mechanically ventilated critically ill adult patients: a secondary analysis of the NEED trial

Lanting Wang
Yi Long
Rongqing Sun
Research25 Nov 2023
European Journal of Clinical Nutrition

Volume: 78, P: 257-263
Maternal gestational diabetes and childhood adiposity risk from 6 to 8 years of age

Weiqin Li
Leishen Wang
Gang Hu
Research20 Dec 2023
International Journal of Obesity

Volume: 48, P: 414-422
Hypothalamic activation is essential for endotoxemia-induced acute muscle wasting

Kaipeng Duan
Qiyi Chen
Ning Li
ResearchOpen Access06 Dec 2016
Scientific Reports

Volume: 6, P: 1-14
Plasma Levels of Alanine Aminotransferase in the First Trimester Identify High Risk Chinese Women for Gestational Diabetes

Junhong Leng
Cuiping Zhang
Xilin Yang
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Pre-sowing Seed Treatments in Direct-seeded Early Rice: Consequences for Emergence, Seedling Growth and Associated Metabolic Events under Chilling Stress

Weiqin Wang
Qian Chen
Lixiao Nie
ResearchOpen Access19 Jan 2016
Scientific Reports

Volume: 6, P: 1-10
Physical Activity, TV Watching Time, Sleeping, and Risk of Obesity and Hyperglycemia in the Offspring of Mothers with Gestational Diabetes Mellitus

Tao Zhang
Peng Wang
Gang Hu
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis

Xuezhen Zeng
Jingying Zhou
Alfred Sze-Lok Cheng
Research02 Sept 2020
Cellular & Molecular Immunology

Volume: 18, P: 1005-1015
Correction: Corrigendum: Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis

Yunan Wang
Abudurexiti Kayoumu
George Liu
Amendments and CorrectionsOpen Access20 Jul 2016
Scientific Reports

Volume: 6, P: 1
Nearly complete redirection of insertion-type indel into recombination enhances knock-in and facilitates endogenous biomolecular condensate analysis

Minglei Huang
Jingjing Fu
Yinqing Li
Correspondence29 Oct 2025
Cell Research

Volume: 35, P: 1079-1082
TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes

Jinhua Liu
Tong Wen
Jiliang Zhou
Research19 Jan 2021
Cell Death & Differentiation

Volume: 28, P: 2045-2059
Effects and cost-effectiveness of a guideline-oriented primary healthcare hypertension management program in Beijing, China: results from a 1-year controlled trial

Xin Wang
Weiqin Li
Yangfeng Wu
Research15 Nov 2012
Hypertension Research

Volume: 36, P: 313-321
miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

Wei Kang
Tingting Huang
Ka Fai To
ResearchOpen Access24 Jan 2018
Cell Death & Disease

Volume: 9, P: 1-16
K-ras^G12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

Yumin Hu
Weiqin Lu
Peng Huang
Research30 Aug 2011
Cell Research

Volume: 22, P: 399-412

Search

Filter By:

Search

Quick links