Placental formation requires an adequate expansion of trophoblast stem and progenitor cells followed by finely tuned lineage specification events. Here, using single-cell analysis of mouse trophoblast stem cells the authors identify Nicol1 as a gatekeeper of the stem cell state and show that CXADR regulates the differentiation dynamics between the two syncytial layers of the mouse placenta.
- Dafina M. Angelova
- Aleksandra Tsolova
- D. Stephen Charnock-Jones
