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Showing 1–7 of 7 results
Advanced filters: Author: Wenfei Kang Clear advanced filters

  • Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an enrichment for STAT3 chromatin binding and elevated expression of KMT2A and DOT1L as dependencies for ERG oncogenicity.

    • Weiran Feng
    • Erik Ladewig
    • Charles L. Sawyers
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 2177-2191

  • Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.

    • George Crowley
    • Robert C. Jones
    • Stephen R. Quake
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • In Saccharomyces cerevisiae, the left arm of chromosome XII only requires 12 genes to maintain cell viability, whereas 25 genes are needed for robust fitness. Here the authors demonstrate that the entire arm can be replaced by a neochromosome with completely artificial sequences.

    • Shuangying Jiang
    • Zhouqing Luo
    • Junbiao Dai
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Sawyers and colleagues describe an in vivo platform used to explore the dynamics and key factors of neuroendocrine lineage transformation. They find that Ascl1 depletion blocks plasticity and leads to cancer that is sensitive to castration.

    • Rodrigo Romero
    • Tinyi Chu
    • Charles L. Sawyers
    ResearchOpen Access
    Nature Cancer
    Volume: 5, P: 1641-1659

  • Hydrogen peroxide and brassinosteroids (BR) both regulate plant development and stress responses. Here Tian et al. show that hydrogen peroxide can trigger oxidation of the BR-responsive BZR1 transcription factor and promote its transcriptional activity, thereby linking BR and redox signaling.

    • Yanchen Tian
    • Min Fan
    • Ming-Yi Bai
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29