Nature Search

Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy

Peritoneal metastasis remains a major clinical challenge due to the lack of effective therapeutic options. In this study, the authors present intraperitoneal programming of tailored chimeric antigen receptor macrophages (CAR-Ms) as a strategy against peritoneal metastasis.

Kedan Gu
Ting Liang
Weihong Tan
ResearchOpen Access24 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial

Siltartoxatug, a first-in-class recombinant monoclonal antibody for tetanus prophylaxis, was shown to be safe and superior to plasma-derived human tetanus immunoglobulin in achieving anti-tetanus neutralizing antibody titers 12 hours after administration.

Zijing Liang
Si Liu
Chuanlin Wang
ResearchOpen Access08 Jul 2025
Nature Medicine

Volume: 31, P: 2673-2681
The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer

CDK4/6 inhibition is a promising therapeutic approach to treat cancer, but it is challenged by resistance development. Here, the authors show that the RNA binding protein LRPPRC forms a positive feedback loop with CDK6 and inhibiting LRPPRC with the FDA-approved gossypol acetate overcomes CDK4/6 inhibition resistance.

Wei Zhou
Wenxi Wang
Xiaohong Fang
ResearchOpen Access14 Jul 2023
Nature Communications

Volume: 14, P: 1-16
Author Correction: Sodium channelopathies in neurodevelopmental disorders

Miriam H. Meisler
Sophie F. Hill
Wenxi Yu
Amendments and Corrections08 Mar 2021
Nature Reviews Neuroscience

Volume: 22, P: 256
On-site biosignal amplification using a single high-spin conjugated polymer

Limitations in performance and stability of organic electrochemical transistors hinder their application in biosignal amplification. Here, the authors show that high-spin, hydrophilic conjugated polymers exhibit ambipolar charge transport properties and can capture and amplify diverse electrophysiological signals.

Gao-Yang Ge
Jingcao Xu
Ting Lei
ResearchOpen Access04 Jan 2025
Nature Communications

Volume: 16, P: 1-10
Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients

Wenxi Yu
Zimei Liu
Zan Shen
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-9
Highly durable organic electrode for sodium-ion batteries via a stabilized α-C radical intermediate

Reactive radical intermediates can be a problem leading to fast degradation of organic electrodes in sodium-ion batteries. Here, the authors show a stabilized α-C radical displaying reversible transformations between C=C, α-C radical and α-C anionic states to facilitate long cycling and improved capacity.

Shaofei Wu
Wenxi Wang
Zhouguang Lu
ResearchOpen Access07 Nov 2016
Nature Communications

Volume: 7, P: 1-11
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Loss of MEN1 affects tumor growth, varing with the components of the tumor microenvironment. These tumors show redistribution of MLL1 on chromatin and the activation of a viral mimicry response.

Peiran Su
Yin Liu
Housheng Hansen He
ResearchOpen Access03 Sept 2024
Nature Genetics

Volume: 56, P: 1890-1902
Fueling sentinel node via reshaping cytotoxic T lymphocytes with a flex-patch for post-operative immuno-adjuvant therapy

Sentinel lymph nodes (SLNs) represent the sites where micro-metastasis can first develop, however they are also important to mount effective anti-tumor immune responses. Here the authors describe the design of a flex-patch loaded with anti-PD-1 antibodies and immuno-adjuvant nanosheets, layered double hydroxide, to fuel anti-tumor immune response in the SLN for postsurgical breast cancer adjuvant therapy.

Bei Li
Guohao Wang
Yunlu Dai
ResearchOpen Access02 May 2023
Nature Communications

Volume: 14, P: 1-15
4.8-μm CO-filled hollow-core silica fiber light source

Xuanxi Li
Linyong Yang
Zefeng Wang
ResearchOpen Access18 Oct 2024
Light: Science & Applications

Volume: 13, P: 1-12
FOXO1 is a master regulator of memory programming in CAR T cells

The transcription factor FOXO1 has a key role in human T cell memory, and manipulating FOXO1 expression could provide a way to enhance CAR T cell therapies by increasing CAR T cell persistence and antitumour activity.

Alexander E. Doan
Katherine P. Mueller
Evan W. Weber
ResearchOpen Access10 Apr 2024
Nature

Volume: 629, P: 211-218
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherapy.

Yan Zhou
Dong Yang
Haiyan Hu
ResearchOpen Access10 Dec 2020
Nature Communications

Volume: 11, P: 1-17
Mitochondrial DNA Mutations Associated with Type 2 Diabetes Mellitus in Chinese Uyghur Population

Wenxi Jiang
Ronghui Li
Mingliang Gu
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-9
Dispersed emergence and protracted domestication of polyploid wheat uncovered by mosaic ancestral haploblock inference

The contribution of ancient haplotypes to domestication is largely unknown. Here, the authors develop an ancestral genomic haploblock dissection method to generate a mosaic pan-ancestry genomic map and reveal that the domesticated polyploidy wheat emerged from the admixture of six founder wild emmer linages.

Zihao Wang
Wenxi Wang
Weilong Guo
ResearchOpen Access06 Jul 2022
Nature Communications

Volume: 13, P: 1-14
Valley resolved dynamics of phonon bottleneck in semiconductor molybdenum ditelluride

The effect of multiple energy valleys in the conduction band of semiconductor molybdenum ditelluride on energy dissipation remains unclear. Here, the authors employ time resolved measurements to reveal the pathways and timescales of carrier relaxation and phonon dynamics in different valleys, identifying the phonon bottlenecks of such relaxation.

Zhong Wang
Yijie Shi
Wenxi Liang
ResearchOpen Access23 Aug 2025
Communications Physics

Volume: 8, P: 1-9
Author Correction: Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Yan Zhou
Dong Yang
Haiyan Hu
Amendments and CorrectionsOpen Access30 Apr 2021
Nature Communications

Volume: 12, P: 1
Increased GDF-15 in chronic male patients with schizophrenia: correlation with body mass index and cognitive impairment

Tianming Guo
Lihua Chen
Peng Chen
ResearchOpen Access19 Dec 2024
Schizophrenia

Volume: 10, P: 1-8
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Developing an ontology of non-pharmacological treatment for emotional and mood disturbances in dementia

Zhenyu Zhang
Ping Yu
Chao Deng
ResearchOpen Access22 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
A Comprehensive Model for Real Gas Transport in Shale Formations with Complex Non-planar Fracture Networks

Ruiyue Yang
Zhongwei Huang
Mao Sheng
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Correction to: Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Shangce Du
Zhi Yang
Wenxian Guan
Amendments and Corrections19 Jan 2022
Oncogene

Volume: 41, P: 1384-1385
Sodium channelopathies in neurodevelopmental disorders

A substantial burden of neurological disease is related to mutations in three sodium channel genes: SCN1A, SCN2A and SCN8A. In this Review, Meisler and colleagues discuss the neurological disorders associated with these mutations and also the therapeutic opportunities that are being investigated as a result of these recent mechanistic insights.

Miriam H. Meisler
Sophie F. Hill
Wenxi Yu
Reviews02 Feb 2021
Nature Reviews Neuroscience

Volume: 22, P: 152-166
Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats

Zhoulong Yu
Ying Han
Jie Shi
Research09 Mar 2022
Molecular Psychiatry

Volume: 27, P: 2522-2532
Interdisciplinary management of combined periodontal-endodontic lesions with palatogingival grooves of the maxillary lateral incisors: a case report

Tong Li
Wenxi He
Shengchao Wang
Research13 Jan 2023
British Dental Journal

Volume: 234, P: 27-33
Attenuated Salmonella carrying plasmid co-expressing HPV16 L1 and siRNA-E6 for cervical cancer therapy

Junyu Chen
Shuhua Zhao
Lijing Zhao
ResearchOpen Access11 Oct 2021
Scientific Reports

Volume: 11, P: 1-14
Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Shangce Du
Zhi Yang
Wenxian Guan
Research02 Aug 2021
Oncogene

Volume: 40, P: 5764-5779
Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae

Michael Salsaa
Bianca Pereira
Miriam L. Greenberg
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Improving satellite-based PM_2.5 estimates in China using Gaussian processes modeling in a Bayesian hierarchical setting

Wenxi Yu
Yang Liu
Jun Bi
ResearchOpen Access01 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity

Wenxi Wang
Anna Shao
Benfang Helen Ruan
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis

Lu Zhang
Chen Lin
Zhi Chen
ReviewsOpen Access07 Jan 2025
International Journal of Oral Science

Volume: 17, P: 1-8
Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

Xingqi Wang
Yuzhi Gao
Ruiqin Yao
ResearchOpen Access15 Jun 2020
Cell Death & Disease

Volume: 11, P: 1-13
Expert consensus on irrigation and intracanal medication in root canal therapy

Xiaoying Zou
Xin Zheng
Lin Yue
ReviewsOpen Access01 Mar 2024
International Journal of Oral Science

Volume: 16, P: 1-10

Search

Intraperitoneal programming of tailored CAR macrophages via mRNA lipid nanoparticle to boost cancer immunotherapy

Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial

The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer

Author Correction: Sodium channelopathies in neurodevelopmental disorders

On-site biosignal amplification using a single high-spin conjugated polymer

Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients

Highly durable organic electrode for sodium-ion batteries via a stabilized α-C radical intermediate

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Fueling sentinel node via reshaping cytotoxic T lymphocytes with a flex-patch for post-operative immuno-adjuvant therapy

4.8-μm CO-filled hollow-core silica fiber light source

FOXO1 is a master regulator of memory programming in CAR T cells

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Mitochondrial DNA Mutations Associated with Type 2 Diabetes Mellitus in Chinese Uyghur Population

Dispersed emergence and protracted domestication of polyploid wheat uncovered by mosaic ancestral haploblock inference

Valley resolved dynamics of phonon bottleneck in semiconductor molybdenum ditelluride

Author Correction: Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Increased GDF-15 in chronic male patients with schizophrenia: correlation with body mass index and cognitive impairment

Deciphering the impact of genomic variation on function

Developing an ontology of non-pharmacological treatment for emotional and mood disturbances in dementia

A Comprehensive Model for Real Gas Transport in Shale Formations with Complex Non-planar Fracture Networks

Correction to: Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Sodium channelopathies in neurodevelopmental disorders

Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats

Interdisciplinary management of combined periodontal-endodontic lesions with palatogingival grooves of the maxillary lateral incisors: a case report

Attenuated Salmonella carrying plasmid co-expressing HPV16 L1 and siRNA-E6 for cervical cancer therapy

Anoikis resistant gastric cancer cells promote angiogenesis and peritoneal metastasis through C/EBPβ-mediated PDGFB autocrine and paracrine signaling

Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae

Improving satellite-based PM_2.5 estimates in China using Gaussian processes modeling in a Bayesian hierarchical setting

Cationic Polymethacrylate-Modified Liposomes Significantly Enhanced Doxorubicin Delivery and Antitumor Activity

Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis

Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells

Expert consensus on irrigation and intracanal medication in root canal therapy

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