Nature Search

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination

For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegans, revealing an epitranscriptomic quality checkpoint tied to male fertility.

Zhenhuan Luo
Yimin Li
Qinghua Zhou
ResearchOpen Access29 Jan 2026
Nature Communications

P: 1-18
Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

This study discovers that tRNA directly binds and regulates the membrane protein FKS1, a β-1,3-glucan synthase essential for fungal cell wall formation. Cryo-EM and biochemical analyses show how tRNA and GSR1 control FKS1 activity and fungal growth.

Jialu Li
Jian Li
Xiang Wang
ResearchOpen Access07 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Protection of Guinea Pigs against Leptospira interrogans Serovar Lai by LipL21 DNA Vaccine

Hanjiang He
Wenyu Wang
Lizhi Tan
Research01 Oct 2008
Cellular & Molecular Immunology

Volume: 5, P: 385-391
Author Correction: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Wenjun Wang
Junyang Tan
Qinghua Zhou
Amendments and CorrectionsOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1
Genome-resolved metagenomics reveals microbiome diversity across 48 tick species

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

Li-Feng Du
Wenyu Shi
Wu-Chun Cao
ResearchOpen Access23 Sept 2025
Nature Microbiology

Volume: 10, P: 2631-2645
Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex

Cryo-EM structures of apo-FKS1 and the FKS1-Rho1 complex reveal how Rho1 activates FKS1, driving conformational changes of FKS1 in β−1,3- glucan synthesis.

Jialu Li
Huayi Liu
Xiang Wang
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Tracing back primed resistance in cancer via sister cells

Transcriptional cell states can drive treatment resistance in cancer. Here, the authors develop ReSisTrace to predict cell states that are primed to resist ovarian cancer treatment and validate their findings using small molecule inhibitors.

Jun Dai
Shuyu Zheng
Anna Vähärautio
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-14
Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans

Transgenerational inheritance (TEI) mechanisms are to some extent conserved across species, but how TEI mediates lipid accumulation is unknown. Here the authors reveal that a network of lipid metabolic genes and chromatin modifications mediated by transcription factors and H3K4 trimethylation work together to achieve multigenerational obesogenic effects in C. elegans fed with a high-fat diet.

Qin-Li Wan
Xiao Meng
Qinghua Zhou
ResearchOpen Access09 Feb 2022
Nature Communications

Volume: 13, P: 1-14
Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Endonuclease G is known to translocate to the nucleus during apoptosis, but less is known about its role in the cytosol. Here, the authors show that cytoplasmic endonuclease G activates mTORC2 signaling and ER stress to promote NAFLD in female mice.

Wenjun Wang
Junyang Tan
Qinghua Zhou
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

Zhang, Xu, Liu, Wang et al. identify an inhibitory mechanism for RIPK1 kinase through EGLN1/pVHL-mediated proline hydroxylation, which is disrupted upon prolonged hypoxia that activates RIPK1 activity to promote cell death and inflammation.

Tao Zhang
Daichao Xu
Wenyi Wei
Research03 Jul 2023
Nature Cell Biology

Volume: 25, P: 950-962
Detection and Attribution of Atmospheric Precipitable Water Changes since the 1970s over China

Jingpeng Zhang
Tianbao Zhao
Wenyu Zhang
ResearchOpen Access26 Nov 2019
Scientific Reports

Volume: 9, P: 1-10
Giant orbital magnetoelectric effect and current-induced magnetization switching in twisted bilayer graphene

The mechanism of current-driven magnetization switching in twisted bilayer graphene (TBG) is poorly understood. Here, He et al. show that a small current can generate a large orbital magnetization due to symmetry breaking by the twisting and substrate in TBG, leading to a giant orbital magnetoelectric effect.

Wen-Yu He
David Goldhaber-Gordon
K. T. Law
ResearchOpen Access03 Apr 2020
Nature Communications

Volume: 11, P: 1-8
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration

Xuri Chen
Yunting Zhou
Hongwei Ouyang
ResearchOpen Access17 Mar 2025
Bone Research

Volume: 13, P: 1-15
Paraquat is an agonist of STIM1 and increases intracellular calcium levels

The herbicide paraquat is an agonist of Stromal Interaction Molecule 1 (STIM1), leading to extracellular calcium entry observed in epithelial-mesenchymal transition in alveolar cells during pulmonary fibrosis.

Wenyu Yang
Rui Tian
Ruilan Wang
ResearchOpen Access30 Oct 2022
Communications Biology

Volume: 5, P: 1-11
PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

Yawen Peng
Shuya Mei
Zhengyu He
ResearchOpen Access01 Apr 2025
Experimental & Molecular Medicine

Volume: 57, P: 759-774
Substantial increase in future fluvial flood risk projected in China’s major urban agglomerations

Urban agglomerations in China are projected to face a 4-to-19-fold increase in flood risk, with the greatest increases in southern China, according to hydrodynamic flood model simulations which account for increases in urban land area

Ruijie Jiang
Hui Lu
Fuqiang Tian
ResearchOpen Access23 Oct 2023
Communications Earth & Environment

Volume: 4, P: 1-11
Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

Peng Chen
Xiaojun Luo
Aimin Li
ResearchOpen Access06 Jul 2020
Experimental & Molecular Medicine

Volume: 52, P: 1062-1074
Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

Yingchao Shi
Luwei Huang
Qian Wu
ResearchOpen Access05 Jan 2024
Cell Research

Volume: 34, P: 193-213
Exogenous auxin represses soybean seed germination through decreasing the gibberellin/abscisic acid (GA/ABA) ratio

Haiwei Shuai
Yongjie Meng
Kai Shu
ResearchOpen Access03 Oct 2017
Scientific Reports

Volume: 7, P: 1-11

Search

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

Protection of Guinea Pigs against Leptospira interrogans Serovar Lai by LipL21 DNA Vaccine

Author Correction: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Genome-resolved metagenomics reveals microbiome diversity across 48 tick species

Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex

Tracing back primed resistance in cancer via sister cells

Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans

Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress

Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

Detection and Attribution of Atmospheric Precipitable Water Changes since the 1970s over China

Giant orbital magnetoelectric effect and current-induced magnetization switching in twisted bilayer graphene

Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration

Paraquat is an agonist of STIM1 and increases intracellular calcium levels

PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

Substantial increase in future fluvial flood risk projected in China’s major urban agglomerations

Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

Decoding the spatiotemporal regulation of transcription factors during human spinal cord development

Exogenous auxin represses soybean seed germination through decreasing the gibberellin/abscisic acid (GA/ABA) ratio

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