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Showing 1–9 of 9 results

Advanced filters: Author: Wesley H. Chou Clear advanced filters

Structural basis and synergism of ATP and Na⁺ activation in bacterial K⁺ uptake system KtrAB

KtrAB complex is essential in K⁺ uptake for bacteria. Here authors illustrate the synergism of ATP and Na⁺ in activating K+ uptake of KtrAB from Bacillus subtilis and its gating mechanism, which may also shed light on other Na⁺-activated K⁺ channels.

Wesley Tien Chiang
Yao-Kai Chang
Nien-Jen Hu
ResearchOpen Access08 May 2024
Nature Communications

Volume: 15, P: 1-14
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap

Optical pooled CRISPR screening is improved by combinatorial oligo hybridization for barcode detection.

Jiacheng Gu
Abhishek Iyer
Jellert T. Gaublomme
ResearchOpen Access07 Oct 2024
Nature Biotechnology

Volume: 43, P: 1101-1115
Clinical targeting of HIV capsid protein with a long-acting small molecule

The small molecule GS-6207, which disrupts the function of the HIV capsid protein, shows potential as a long-acting therapeutic agent for the treatment and prevention of HIV infection.

John O. Link
Martin S. Rhee
Tomas Cihlar
Research01 Jul 2020
Nature

Volume: 584, P: 614-618
Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone

L Endo-Munoz
A Cumming
N A Saunders
ResearchOpen Access15 Jun 2010
British Journal of Cancer

Volume: 103, P: 73-81
A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

A new compound that inhibits HIV capsid assembly and nuclear transport functions offers potential as a long-acting antiretroviral.

Stephen R. Yant
Andrew Mulato
John O. Link
Research09 Sept 2019
Nature Medicine

Volume: 25, P: 1377-1384
Influence of substance use on male reproductive health and offspring outcomes

Paternal substance use is associated with adverse effects on male reproductive health and offspring health outcomes. Comprehensive counselling by health-care providers and improved public health measures, especially targeting reproductive-age men, are needed.

Jamie O. Lo
Jason C. Hedges
Charles A. Easley IV
Reviews25 Apr 2024
Nature Reviews Urology

Volume: 21, P: 534-564
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts

Tien Dam
Gennaro Pagano
Dilinuer Wubuli
ResearchOpen Access27 Sept 2024
npj Parkinson's Disease

Volume: 10, P: 1-12
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2