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T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Analysis of peripheral mycobacteria-reactive CD4⁺ T cell receptor sequences from individuals infected with Mycobacterium tuberculosis shows a high degree of overlap between progressors and controllers, but points to some distinct clonotypes that are enriched in either group.

Munyaradzi Musvosvi
Huang Huang
Tran Van
ResearchOpen Access05 Jan 2023
Nature Medicine

Volume: 29, P: 258-269
Correction: Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

Helen A. Fletcher
Margaret A. Snowden
Helen McShane
Amendments and CorrectionsOpen Access06 May 2016
Nature Communications

Volume: 7, P: 1
Dominant TNF-α⁺ Mycobacterium tuberculosis–specific CD4⁺ T cell responses discriminate between latent infection and active disease

Discriminating between active and latent infection with Mycobacterium tuberculosis (Mtb) is a protracted and complicated process, which can affect the timeliness of treatment decisions. Harari et al. now report that the cytokine profiles of Mtb-specific CD4⁺ T cells characterized by a polychromatic flow cytometry assay can distinguish latent infection from active disease.

Alexandre Harari
Virginie Rozot
Giuseppe Pantaleo
Research20 Feb 2011
Nature Medicine

Volume: 17, P: 372-376
HIV transmission dynamics and population-wide drug resistance in rural South Africa

There is limited data on drug resistance in South African communities strongly affected by HIV. In this study, the authors observed low levels of resistance to newer drugs but widespread resistance to older HIV medications in a South African community. Resistance to rilpivirine was detected even in untreated individuals.

Steven A. Kemp
Kimia Kamelian
Ravindra K. Gupta
ResearchOpen Access29 Apr 2024
Nature Communications

Volume: 15, P: 1-13
Lymphocyte subsets and proliferation at presentation and during the therapeutic course of childhood tuberculosis. † 713

Willem A Hanekom
Jane Hughes
Gregory D Hussey
Research01 Apr 1997
Pediatric Research

Volume: 41, P: 121
Influenza Vaccination in HIV-Infected Children: Serologic Response, Viral Load Changes and Effect of Vitamin A Supplementation ♦ 844

Willem A Hanekom
Lynn M Heald
Ellen Gould Chadwick
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 146
THE HEMATOLOGIC SPECTRUM OF CHILDHOOD TUBERCULOSIS. 918

Willem A Hanekom
Stephanus Potgieter
Gregory Hussey
Research01 Apr 1996
Pediatric Research

Volume: 39, P: 155
Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Cross-neutralization assays of early variants and the 501Y.V2 variant of SARS-CoV-2 show that plasma from individuals infected with 501Y.V2 effectively neutralizes all variants, indicating that a vaccine that targets 501Y.V2 may also be effective against other SARS-CoV-2 variants.

Sandile Cele
Inbal Gazy
Alex Sigal
Research29 Mar 2021
Nature

Volume: 593, P: 142-146
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pronounced in vaccinated individuals.

Khadija Khan
Farina Karim
Alex Sigal
ResearchOpen Access10 Aug 2022
Nature Communications

Volume: 13, P: 1-7
Omicron infection enhances Delta antibody immunity in vaccinated persons

A study quantifying the neutralization of severe acute respiratory syndrome coronavirus 2 variants in individuals infected with Omicron/BA.1 shows that vaccinated individuals previously infected with Omicron have enhanced protection against reinfection with current variants, \including Omicron/BA.2, while Omicron/BA.1 infected unvaccinated individuals have limited protection.

Khadija Khan
Farina Karim
Alex Sigal
ResearchOpen Access06 May 2022
Nature

Volume: 607, P: 356-359
Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation

There is limited data on immune factors contributing to SARS-CoV-2 viral clearance in people living with HIV. Here, the authors show that re-emergence of the neutralizing antibody response may be key to clearing persistent SARS-CoV-2 infection in ART-mediated recovery from immunosuppression in advanced HIV disease.

Farina Karim
Catherine Riou
Alex Sigal
ResearchOpen Access15 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Author Correction: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Khadija Khan
Farina Karim
Alex Sigal
Amendments and CorrectionsOpen Access13 Oct 2022
Nature Communications

Volume: 13, P: 1
Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.

Sandile Cele
Laurelle Jackson
Alex Sigal
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 654-656
Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

Roshni Roy Chowdhury
Francesco Vallania
Yueh-hsiu Chien
Amendments and Corrections30 Oct 2018
Nature

Volume: 564, P: E5
T-cell activation is an immune correlate of risk in BCG vaccinated infants

BCG vaccine confers only partial protection against tuberculosis. Here the authors show that the risk of tuberculosis infection and progression to disease in BCG-immunized children positively correlates with the frequency of activated HLA-DR⁺CD4⁺T cells.

Helen A. Fletcher
Margaret A. Snowden
Helen McShane
ResearchOpen Access12 Apr 2016
Nature Communications

Volume: 7, P: 1-11
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Metabolite changes in blood predict the onset of tuberculosis

The tuberculosis pandemic requires new methods for diagnosing and containing infections prior to active disease. Here, the authors performed a multi-site observational study within sub-Saharan Africa and present serum and plasma metabolic signatures that can predict the onset of active TB with a high degree of sensitivity and specificity.

January Weiner 3rd
Jeroen Maertzdorf
Sarah Zalwango
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-12
Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

Robert G. E. Krause
Thandeka Moyo-Gwete
Alasdair Leslie
ResearchOpen Access12 Aug 2023
npj Vaccines

Volume: 8, P: 1-15
Immunological biomarkers of tuberculosis

The improvement of tuberculosis diagnosis and treatment regimens depends on the identification of suitable biomarkers. Analysis of host immunological markers at diagnosis and throughout treatment may aid new drug development and the clinical management of individual patients.

Gerhard Walzl
Katharina Ronacher
Alimuddin Zumla
Reviews08 Apr 2011
Nature Reviews Immunology

Volume: 11, P: 343-354
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

Integrated analyses of multiple cohorts are used to obtain a better understanding of the immune state of latent infection with Mycobacterium tuberculosis, and factors that mediate and/or predict transitions from latent infection to active disease.

Roshni Roy Chowdhury
Francesco Vallania
Yueh-hsiu Chien
Research22 Aug 2018
Nature

Volume: 560, P: 644-648
COMPASS identifies T-cell subsets correlated with clinical outcomes

Computational analysis of antigen-specific T cell subsets highlights individual-level variation in immune response quality.

Lin Lin
Greg Finak
Raphael Gottardo
Research25 May 2015
Nature Biotechnology

Volume: 33, P: 610-616
Computer-aided interpretation of chest radiography reveals the spectrum of tuberculosis in rural South Africa

Jana Fehr
Stefan Konigorski
Zizile Sikhosana
ResearchOpen Access02 Jul 2021
npj Digital Medicine

Volume: 4, P: 1-10
RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Adam Penn-Nicholson
Stanley Kimbung Mbandi
Lara Lewis
ResearchOpen Access25 May 2020
Scientific Reports

Volume: 10, P: 1-21
Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Mateusz Hasso-Agopsowicz
Thomas J. Scriba
Steven G. Smith
ResearchOpen Access30 Aug 2018
Scientific Reports

Volume: 8, P: 1-11
Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

Reto Guler
Thabo Mpotje
Frank Brombacher
ResearchOpen Access12 Dec 2018
Mucosal Immunology

Volume: 12, P: 390-402
Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion

M S Shey
A K Randhawa
W A Hanekom
Research06 May 2010
Genes & Immunity

Volume: 11, P: 561-572
Publisher Correction: Computer-aided interpretation of chest radiography reveals the spectrum of tuberculosis in rural South Africa

Jana Fehr
Stefan Konigorski
Zizile Sikhosana
Amendments and CorrectionsOpen Access16 Jul 2021
npj Digital Medicine

Volume: 4, P: 1
Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines

Virginie Rozot and Elisa Nemes et al. report comprehensive profiling of immune responses from participants in a recent clinical trial of the H4:IC31 and BCG vaccines against Mycobacterium tuberculosis infection. Using a novel analysis platform, they uncover complex vaccine-induced modulation of different immune cell subsets.

Virginie Rozot
Elisa Nemes
Noncedo Xoyana
ResearchOpen Access09 Oct 2020
Communications Biology

Volume: 3, P: 1-12

Search

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

Correction: Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

Dominant TNF-α⁺ Mycobacterium tuberculosis–specific CD4⁺ T cell responses discriminate between latent infection and active disease

HIV transmission dynamics and population-wide drug resistance in rural South Africa

Lymphocyte subsets and proliferation at presentation and during the therapeutic course of childhood tuberculosis. † 713

Influenza Vaccination in HIV-Infected Children: Serologic Response, Viral Load Changes and Effect of Vitamin A Supplementation ♦ 844

THE HEMATOLOGIC SPECTRUM OF CHILDHOOD TUBERCULOSIS. 918

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

Diminishing benefits of urban living for children and adolescents’ growth and development

Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Omicron infection enhances Delta antibody immunity in vaccinated persons

Clearance of persistent SARS-CoV-2 associates with increased neutralizing antibodies in advanced HIV disease post-ART initiation

Author Correction: Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

T-cell activation is an immune correlate of risk in BCG vaccinated infants

Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Metabolite changes in blood predict the onset of tuberculosis

Infection pre-Ad26.COV2.S-vaccination primes greater class switching and reduced CXCR5 expression by SARS-CoV-2-specific memory B cells

Immunological biomarkers of tuberculosis

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

COMPASS identifies T-cell subsets correlated with clinical outcomes

Computer-aided interpretation of chest radiography reveals the spectrum of tuberculosis in rural South Africa

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases

Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion

Publisher Correction: Computer-aided interpretation of chest radiography reveals the spectrum of tuberculosis in rural South Africa

Multidimensional analyses reveal modulation of adaptive and innate immune subsets by tuberculosis vaccines

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