Nature Search

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Sanna Gudmundsson
Moriel Singer-Berk
Anne O’Donnell-Luria
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Development of chronic colitis is dependent on the cytokine MIF

Ype P. de Jong
Ana C. Abadia-Molina
Cox Terhorst
Research22 Oct 2001
Nature Immunology

Volume: 2, P: 1061-1066
Long-term SARS-CoV-2 RNA shedding and its temporal association to IgG seropositivity

Vineet Agarwal
A. J. Venkatakrishnan
Venky Soundararajan
ResearchOpen Access02 Dec 2020
Cell Death Discovery

Volume: 6, P: 1-9
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn’s disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.

Aleksejs Sazonovs
Christine R. Stevens
Mark J. Daly
Research29 Aug 2022
Nature Genetics

Volume: 54, P: 1275-1283
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

SLAM is best known for its homotypic costimulatory molecule functions. Terhorst and colleagues now demonstrate that it also acts as a sensor for Gram-negative bacteria and regulates the antibacterial response.

Scott B Berger
Xavier Romero
Cox Terhorst
Research05 Sept 2010
Nature Immunology

Volume: 11, P: 920-927
The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Environmental enteric dysfunction (EED) is an important cause of impaired development and stunting in children in the developing world. In this Consensus Statement, the authors assess the potential of optical biopsy technologies to facilitate the study and diagnosis of this global burden.

Alex J. Thompson
Michael Hughes
Guang-Zhong Yang
ReviewsOpen Access15 Nov 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 727-738
RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease

Robyn Laura Kosinsky
Maria Zerche
Steven A. Johnsen
ResearchOpen Access04 Jun 2021
Cell Death & Differentiation

Volume: 28, P: 3161-3175
Author Correction: Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel

Bram Verstockt
Stefania Vetrano
Severine Vermeire
Amendments and Corrections07 Mar 2022
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 410
Plasma IL-6 levels following corticosteroid therapy as an indicator of ICU length of stay in critically ill COVID-19 patients

Samir Awasthi
Tyler Wagner
Venky Soundararajan
ResearchOpen Access15 Mar 2021
Cell Death Discovery

Volume: 7, P: 1-15
JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

The biological effects of cytokines in intestinal homeostasis and disease occur as a result of JAK–STAT signalling. This Review describes the current understanding of JAK–STAT signalling in intestinal homeostasis and inflammatory bowel disease as well as the rationale for therapeutically targeting this pathway.

Azucena Salas
Cristian Hernandez-Rocha
Niels Vande Casteele
Reviews19 Mar 2020
Nature Reviews Gastroenterology & Hepatology

Volume: 17, P: 323-337
In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study

Kathan Mehta
Palashkumar Jaiswal
Maneesh Dave
ResearchOpen Access01 May 2018
Scientific Reports

Volume: 8, P: 1-10
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease

IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL-12 and/or IL-23.

Bram Verstockt
Azucena Salas
Stefania Vetrano
Reviews17 Apr 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 433-446
Measurement of gut permeability using fluorescent tracer agent technology

Richard B. Dorshow
Carla Hall-Moore
Phillip I. Tarr
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease

Intestinal immune cell trafficking is a tightly regulated process involved in health and disease. This Review discusses the sphingosine 1-phosphate modulators as therapeutic agents in targeting leukocyte trafficking and inflammation in inflammatory bowel disease.

Bram Verstockt
Stefania Vetrano
Severine Vermeire
Reviews14 Feb 2022
Nature Reviews Gastroenterology & Hepatology

Volume: 19, P: 351-366

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