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Showing 1–2 of 2 results
Advanced filters: Author: Wonyul Jang Clear advanced filters

  • The interplay between non-vesicular lipid transport, calcium signaling, and membrane dynamics is unclear. Here, the authors report a function for inositol triphosphate hydrolysis by the inositol 5-phosphatase INPP5A in controlling lipid exchange at interorganelle membrane contact sites between the endoplasmic reticulum and Golgi.

    • Mouhannad Malek
    • Anna M. Wawrzyniak
    • Volker Haucke
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Phosphoinositides are signalling, membrane lipids derived from phosphatidylinositol, whose intracellular distribution and interconversion via phosphoinositide kinases and phosphatases is tightly coupled to membrane dynamics. Accordingly, phosphoinositides are now recognized as key regulators of endocytic and exocytic traffic, the autolysosomal system, and membrane contact site organization and function.

    • York Posor
    • Wonyul Jang
    • Volker Haucke
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 797-816