Nature Search

The microbiota of the respiratory tract: gatekeeper to respiratory health

The respiratory tract spans from the nostrils to the lung alveoli and these distinct niches host a diverse microbiota. In this Review, Man, de Steenhuijsen Piters and Bogaert discuss the role of the respiratory microbiota in the maintenance of human health.

Wing Ho Man
Wouter A.A. de Steenhuijsen Piters
Debby Bogaert
Reviews20 Mar 2017
Nature Reviews Microbiology

Volume: 15, P: 259-270
Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers

Jeremia J. Pyuza
Marloes M. A. R. van Dorst
Wouter A. A. de Steenhuijsen Piters
ResearchOpen Access19 Jun 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-15
Higher off-target amplicon detection rate in MiSeq v3 compared to v2 reagent kits in the context of 16S-rRNA-sequencing

Mari-Lee Odendaal
James A. Groot
Wouter A. A. de Steenhuijsen Piters
ResearchOpen Access01 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
Early-life viral infections are associated with disadvantageous immune and microbiota profiles and recurrent respiratory infections

Longitudinal multi-omic analysis of 114 healthy infants from birth to 12 months of age showed that first viral encounters are associated with airway inflammation, changes in respiratory microbiota and later susceptibility to clinical respiratory tract infections.

Wouter A. A. de Steenhuijsen Piters
Rebecca L. Watson
Debby Bogaert
Research20 Jan 2022
Nature Microbiology

Volume: 7, P: 224-237
Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Using a Streptococcus pneumoniae human challenge model, the authors here show that baseline nasal microbiota profiles are associated with pneumococcal acquisition and density, independent of live-attenuated influenza vaccine (LAIV) administration, and with mucosal cytokine responses to LAIV.

Wouter A. A. de Steenhuijsen Piters
Simon P. Jochems
Debby Bogaert
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Pneumococcal carriage in the upper respiratory tract is an important determinant of influenza severity. Jochems et al. use human systems analysis to show that influenza-induced inflammation increases bacterial burden in the nasal cavity with implications for secondary bacterial pneumonia.

Simon P. Jochems
Fernando Marcon
Daniela M. Ferreira
Research29 Oct 2018
Nature Immunology

Volume: 19, P: 1299-1308
Bacterial and fungal communities in tracheal aspirates of intubated COVID-19 patients: a pilot study

Alicia Ruiz-Rodriguez
Paula Lusarreta-Parga
Debby Bogaert
ResearchOpen Access14 Jun 2022
Scientific Reports

Volume: 12, P: 1-10
Benchmarking laboratory processes to characterise low-biomass respiratory microbiota

Raiza Hasrat
Jolanda Kool
Thijs Bosch
ResearchOpen Access25 Aug 2021
Scientific Reports

Volume: 11, P: 1-13
Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life

Kristen L. Lokken-Toyli
Wouter A. A. de Steenhuijsen Piters
Jeffrey N. Weiser
Research31 Aug 2021
Mucosal Immunology

Volume: 14, P: 1358-1368
Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

Wouter A A de Steenhuijsen Piters
Elisabeth G W Huijskens
Debby Bogaert
Research07 Jul 2015
The ISME Journal

Volume: 10, P: 97-108

Search

The microbiota of the respiratory tract: gatekeeper to respiratory health

Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers

Higher off-target amplicon detection rate in MiSeq v3 compared to v2 reagent kits in the context of 16S-rRNA-sequencing

Early-life viral infections are associated with disadvantageous immune and microbiota profiles and recurrent respiratory infections

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Bacterial and fungal communities in tracheal aspirates of intubated COVID-19 patients: a pilot study

Benchmarking laboratory processes to characterise low-biomass respiratory microbiota

Decreased production of epithelial-derived antimicrobial molecules at mucosal barriers during early life

Dysbiosis of upper respiratory tract microbiota in elderly pneumonia patients

Search

Quick links

Search

Filter By:

Search

Quick links