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Zero-knowledge proofs can protect privacy online, but almost all current methods are vulnerable to quantum attacks. Here, the authors report an efficient relativistic protocol and experiment that resists quantum attacks and greatly reduces runtime, randomness cost and communication rounds.

Genetically encoded fluorescent biosensors are valuable tools for metabolite monitoring. Here, authors report a versatile strategy to design such biosensors via regulatory domains of allosteric enzymes, showing that the developed tools support sensitive detection of target metabolites in vitro and in live cells.

Heat exposure is associated with increased emergency department visits across multiple territories, with distinct vulnerability patterns by region and cause. These findings inform targeted adaptation strategies and healthcare resource allocation under increasingly severe heat events.

Turning lignin oils into nylon ingredients is hard because key bonds resist breaking and products overreact. A light-driven catalyst makes cyclohexanones without added hydrogen and enables tougher, clearer polyamides.

A spatiotemporal transcriptome atlas of whole-human embryos after gastrulation and previously transcriptionally undescribed stages of human development are reported.

Designing improved halide solid electrolytes holds the key to the success of all-solid-state batteries. Here, authors present the design of SSEs through functional modules, introducing LaCl3, which possesses a UCl3 structure, as well as low-cost and low-density AlF3, to enable low-temperature application and improve moisture and high-voltage stability in halide-based solid-state battery systems.

In mice, a next-generation gene therapy for spinal muscular atrophy improved survival and motor function more than a Zolgensma-like treatment, with fewer signs of liver and heart toxicity, supporting its promise as a safer, more effective approach.

Alcohol oxidation plays a crucial role in renewable energy, but its efficiency is typically limited by complex surface dynamics. Here, the authors show that alkali metal cations modulate hydroxyl adsorption on platinum-based catalysts, achieving a kinetic balance that boosts performance.

Soft robotics are promising to maneuver through complex environments, though it is challenging to design adaptable devices. Here the authors use a liquid crystal elastomer-based system to design a tunneling robot which can disrupt clogs in a model vascular system.

The arrestin-mediated regulation of signaling through the metabotropic glutamate receptors (mGlus) is fundamental for synapse function. Here, authors report multiple subtype-dependent arrestin binding modes of the mGlus that account for their differential signaling profiles.

Patients with hepatocellular carcinoma (HCC) with Vp4 portal vein tumour thrombus (PVTT) have poor prognosis and are underrepresented in clinical trials. Here, the authors report a phase 2 clinical trial evaluating first-line durvalumab (anti-PD-L1) plus HAIC-FOLFOX (hepatic arterial infusion chemotherapy) in patients with HCC with Vp4 PVTT, along with biomolecular and preclinical analysis.

The efficacy and safety of albumin combined with endovascular therapy for acute ischemic stroke remain unclear. Here, the authors show in a randomized multicenter trial that albumin treatment reduces infarct volume growth compared with placebo without increasing safety risks.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

This study examines severe lattice distortions in concentrated solid solutions, enabling an energy landscape that immobilizes vacancies and interstitials which curbs their harmful evolution under irradiation conditions.

Decreased intestinal barrier integrity contributes to progression of digestive system tumors. Here the authors report the design and characterization of enterocyte-mimetic butyrate-loaded nanoparticles, showing reduced disruption of the intestinal barrier and inhibited tumor progression after oral delivery.

Current artificial vision systems suffer from high energy consumption and latency due to the von Neumann bottleneck and separated spatiotemporal processing. Wu et al. propose a vision system achieving native spatiotemporal co-processing with millisecond latency and 95% action recognition accuracy at low computational cost.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Rising boreal insolation enhanced poleward heat transport and Nordic Seas warming since the late LGM, triggering the initial Eurasian Ice Sheet collapse. The resulting meltwater led to early AMOC weakening and acceleration of the deglaciation process.

Nonreciprocal magneto-transport is often attributed to Zeeman-driven mechanisms. Here, the authors identify Lorentz skew scattering nonreciprocal magneto-transport in BiTeBr which emerges from the cooperation of classical Lorentz force and quantum skew scattering.

Biomass electro-hydrogenation offers a sustainable route to value-added chemicals but suffers poor selectivity at high current densities. Here, the authors report an amide-functionalized Cu₃N catalyst enabling near-quantitative HMF-to-DHMF conversion under industrially relevant conditions.

Epigenetic dysregulation is a central driver of the progressive remodeling seen in idiopathic pulmonary fibrosis with specific factors to be further explored. The authors here show Hdac11 drives lung fibrosis by repressing Parkin-dependent mitophagy, which is associated with enhanced macrophage M2-type polarization and myofibroblast trans-differentiation.

Electrosynthesis of 1,3-butadiene from dilute coal-derived acetylene is promising yet remains challenging due to competing side reactions. Here, the authors develop coordination-modulated dicopper molecular catalysts to steer the electrocatalytic dilute acetylene toward 1,3-butadiene.

Controlling hierarchical chirality is of critical importance for the design of nanomaterials with enantioselective functionality. Here, the authors synthesize multiscale chiral Pt@Au nanostructures that enable plasmon-enhanced enantioselective electrochemical detection.

Existing Janus hydrogels struggle to combine high-strength, asymmetric adhesion, and simple fabrication. Here, the authors develop a high-strength Janus hydrogel with bilateral asymmetric adhesion for wet tissue hemostasis and intestinal/intrauterine anti-adhesion.

The physiologic roles of the neurotransmission from PVHCRH neurons remain untested. Here, authors show differential roles of glutamate and CRH release from PVHCRH neurons in diet-induced obesity but a permissive role for their release in the HPA axis.

This work establishes a relationship between the cavity radius of hydrated electrons and PFAS degradation, which shifts focus from PFAS structure to reactive species structures, thus opening an overlooked way to tune advanced reduction processes.

In zebrafish, cholecystokinin drives gonadal development via two parallel pathways: direct FSH stimulation in the pituitary and local regulation of germ cell proliferation and survival within the gonad.

Difelikefalin is an FDA-approved KOR-targeted drug for chronic pruritus yet exhibits side effects. Here, researchers solve cryo-EM structure of difelikefalin KOR-Gi, identifying Y320^7.43 as a key bias residue. Substituting D-Phe1 with β-phenylalanine develops beta01 which retains analgesic/antipruritic efficacy via a unique receptor conformation that reduces adverse effects.

Ketogenic diet (KD) generates β-hydroxybutyrate metabolites and has been shown to have context-dependent immunomodulatory effects. However, the effects of KD on inflammatory bowel disease (IBD) are controversial. Here, the authors investigate the pathogenic effects of KD in a preclinical model of DSS-induced colitis and identify a β-HB-Thomasclavelia spiroformis-γδ17 T cell axis that exacerbates inflammation and mucosal damage.

This work synergistically improves piezoelectricity and temperature stability of lead-free piezoceramics via a multilayer architecture, demonstrating its application potential for accelerometers.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

The gut microbial-derived metabolite HMB induces hepatic SNHG9, which suppresses MYC translation via IMP2, thereby derepressing MAS expression. MAS promotes protective autophagy, and HMB supplementation mitigates acetaminophen-induced liver injury.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

Intramolecular C– H insertion provides direct access to indolines, but conventional approaches tend to produce ungoverned mixtures of indolines and indoles, owing to harsh conditions. Herein, the authors report a switchable synthetic platform that enables tunable access to either scaffold.

Here authors present a method combining DFT calculations with experimental synthesis to address the challenges of slow recovery and limited recyclability in chemiresistive sensing MOFs.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Metabolic reprogramming in cancer cells can contribute to responsiveness to immunotherapy. In this study, glucose deprivation in hepatocellular carcinoma cells was found to promote OXCT1 S113 phosphorylation, which leads to its translocation to the nucleus, association with IRF1 and suppression of MHC-I and chemokine gene transcription.

A room-temperature ferroelectricity with out-of-plane polarization is disclosed in chemical vapor deposition synthesized two-dimensional α-MnS, which exhibits large tunneling electroresistance, high endurance, and long retention time.

Prunus subgenus Cerasus comprises over 70 species with ornamental, edible, and medicinal value. Here, the authors assemble eight genomes from wild and cultivated Cerasus species, construct pangenome together with 13 public genomes, and uncover the evolutionary origin and genetic determinants of flower development.

Inspired by plant physiology, researchers developed a biomimetic sensing element of Cu₂Cyt/MXene and built a noble-metal-free, wearable ethylene gas sensor with low detection limit, fast response, high selectivity, and room-temperature operation.

Epithelial-mesenchymal transition (EMT) is a common mechanism for acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Here, the authors discover that ZEB1-mediated repression of ELMO3 creates a synthetic-lethal dependence on ELMO2, and that inhibiting ELMO2 selectively kills mesenchymal-like cells and EGFR TKIs–resistant cancer cells.