The Set8-Set7 methyltransferase plays a critical role in cell cycle progression and tumorigenesis, and is degraded through modification by the E3 ubiquitin ligase CRL4Cdt2. Here Wang et al. identify SCFβ-TRCPas an additional E3 ubiquitin ligase that marks Set8 for degradation in response to DNA damage.
- Zhiwei Wang
- Xiangpeng Dai
- Wenyi Wei