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YAP charge patterning mediates signal integration through transcriptional co-condensates

Transcriptional condensates concentrate gene regulatory proteins to control gene activation. Meyer et al. demonstrate that charge-mediated co-condensation of YAP and the oppositely charged transcriptional scaffold Med1 drives transcriptional activation.

Kirstin Meyer
Klaus Yserentant
Orion D. Weiner
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Author Correction: MYC phase separation selectively modulates the transcriptome

Junjiao Yang
Chan-I Chung
Xiaokun Shu
Amendments and Corrections12 Jun 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1808
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2

A fluorogenic reporter allows visualization of spike protein and ACE2 receptor interaction and the identification of natural products that inhibit SARS-CoV-2 replication in vitro and in vivo.

Junjiao Yang
Yinghong Xiao
Xiaokun Shu
Research05 Jan 2023
Nature Microbiology

Volume: 8, P: 121-134
Correction: Corrigendum: A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein

Erik A Rodriguez
Geraldine N Tran
Roger Y Tsien
Amendments and Corrections29 Sept 2016
Nature Methods

Volume: 13, P: 890
MYC phase separation selectively modulates the transcriptome

Oncoprotein transcription factor MYC undergoes phase separation, forming transcriptionally active condensates. The chemogenetic tool SPARK-ON reveals that MYC phase separation selectively modulates the transcriptome and promotes cell proliferation.

Junjiao Yang
Chan-I Chung
Xiaokun Shu
Research29 May 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1567-1579
Designed peptides that assemble into cross-α amyloid-like structures

Structural analysis reveals how certain designed peptides adopt unusual spiraling cross-α amyloid-like structures and also rearrange to helical polymers upon mutation of small nonpolar residues that are critical for packing and stabilization.

Shao-Qing Zhang
Hai Huang
William F. DeGrado
Research30 Jul 2018
Nature Chemical Biology

Volume: 14, P: 870-875
Theoretical and experimental study of thermo electrical coupling mechanisms in coal bearing rocks

Xiaokun Zhao
Jun Ge
Weixia Fu
ResearchOpen Access01 Dec 2025
Scientific Reports

Volume: 16, P: 1-19
Polarized focal adhesion kinase activity within a focal adhesion during cell migration

Engineering of a focal adhesion kinase (FAK) reporter that visualizes endogenous FAK activity with dynamic spatiotemporal resolution in living cells and vertebrates reveals tension-induced polarized FAK activity in single focal adhesions during cell migration.

Xiaoquan Li
Joseph Dale Combs III
Xiaokun Shu
Research22 Jun 2023
Nature Chemical Biology

Volume: 19, P: 1458-1468
Singlet oxygen triplet energy transfer-based imaging technology for mapping protein–protein proximity in intact cells

Fluorescence imaging can be used for the characterization of protein interactions in cells, although typical methods require the interacting groups to be quite close. Here, the authors present a fluorescent technique using singlet oxygen for the imaging of more distant protein–protein interactions.

Tsz-Leung To
Michael J. Fadul
Xiaokun Shu
Research06 Jun 2014
Nature Communications

Volume: 5, P: 1-9
An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging

Infrared fluorescent proteins offer advantages for deep in vivo imaging thanks to the tissue-penetrating properties of infrared light. Here, Yu et al. design a monomeric infrared fluorescent protein that, when combined with expression of haeme oxygenase in cells, shows improved performance for in vivoimaging of neurons and brain tumours.

Dan Yu
William Clay Gustafson
Xiaokun Shu
Research15 May 2014
Nature Communications

Volume: 5, P: 1-7
A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein

A bright and photostable far-red fluorescent protein, smURFP, was developed from a cyanobacterial phycobiliprotein. smURFP uniquely binds a highly cell-permeable biliverdin derivative to obtain fluorescence brightness comparable to that of eGFP in cells.

Erik A Rodriguez
Geraldine N Tran
Roger Y Tsien
Research01 Aug 2016
Nature Methods

Volume: 13, P: 763-769
Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry

PROTACs have emerged as promising therapeutic agents but their cellular uptake is often inefficient. Here, the authors show that reversible covalent warhead chemistry improves PROTAC intracellular accumulation and target engagement, and develop a dual inhibitor/degrader of Bruton’s tyrosine kinase

Wen-Hao Guo
Xiaoli Qi
Jin Wang
ResearchOpen Access26 Aug 2020
Nature Communications

Volume: 11, P: 1-16
A naturally monomeric infrared fluorescent protein for protein labeling in vivo

An infrared fluorescent protein based on a new monomeric scaffold is described in this paper and is tested for protein fusion in cells and in vivo.

Dan Yu
Michelle A Baird
Xiaokun Shu
Research22 Jun 2015
Nature Methods

Volume: 12, P: 763-765
Tailing miniSOG: structural bases of the complex photophysics of a flavin-binding singlet oxygen photosensitizing protein

Joaquim Torra
Céline Lafaye
Antoine Royant
ResearchOpen Access20 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

Butko and colleagues report the invention of fluorescent and photo-oxidizing versions of a molecular probe named TimeSTAMP that allows temporal tagging of newly synthesized proteins of interest. The study uses these new tools to track basal and pharmacologically-induced synthesis of the synaptic protein PDS-95 in real time via live fluorescent imaging and/or with ultrastructural resolution using electron microscopy.

Margaret T Butko
Jin Yang
Michael Z Lin
Research28 Oct 2012
Nature Neuroscience

Volume: 15, P: 1742-1751
An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

Yiyue Ge
Tingzhong Tian
Jianyang Zeng
ResearchOpen Access24 Apr 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-16

Search

YAP charge patterning mediates signal integration through transcriptional co-condensates

Author Correction: MYC phase separation selectively modulates the transcriptome

Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2

Correction: Corrigendum: A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein

MYC phase separation selectively modulates the transcriptome

Designed peptides that assemble into cross-α amyloid-like structures

Theoretical and experimental study of thermo electrical coupling mechanisms in coal bearing rocks

Polarized focal adhesion kinase activity within a focal adhesion during cell migration

Singlet oxygen triplet energy transfer-based imaging technology for mapping protein–protein proximity in intact cells

An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging

A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein

Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry

A naturally monomeric infrared fluorescent protein for protein labeling in vivo

Tailing miniSOG: structural bases of the complex photophysics of a flavin-binding singlet oxygen photosensitizing protein

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

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