Self-amplifying mRNA (saRNA) vaccines hold promise for enhanced immunogenicity. This study in mice demonstrates that saRNA vaccines elicit an adaptive immune response against their own replicase, weakening T-cell responses to a subsequent H5N1 saRNA vaccine, but not diminishing the protective efficacy against an H5N1 virus challenge.
- Xiaole Cui
- Laura Amelinck
- Niek N. Sanders