Nature Search

Crinophagic granules in pancreatic β cells contribute to mouse autoimmune diabetes by diversifying pathogenic epitope repertoire

Dense-core granules (DCG) store insulin in pancreatic β cells. Here the authors show that crinosome, formed by fusing lysosome and DCGs, are pathogenic in mouse models of type 1 diabetes by diversifying local insulin epitopes beyond those tolerizing ones expressed in the thymus, thereby inducing autoreactive CD4 T cells for β cell death and insulin deficiency.

Hao Hu
Anthony N. Vomund
Xiaoxiao Wan
ResearchOpen Access27 Sept 2024
Nature Communications

Volume: 15, P: 1-22
Publisher Correction: The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Xiaoxiao Wan
Anthony N. Vomund
Emil R. Unanue
Amendments and Corrections01 Apr 2020
Nature Immunology

Volume: 21, P: 589
Marine sedimentary evidence reveals East Asian Winter Monsoon forcing on Neolithic Cultural transitions in Central and Eastern China

Abrupt monsoon intensification in Eastern China triggered agricultural stress and Neolithic cultural transitions, according to analysis of a high-resolution sea-surface temperature record from the southern Yellow Sea.

Run Yuan
Rui Zhang
Shiyang Xu
ResearchOpen Access02 Mar 2026
Communications Earth & Environment

Volume: 7, P: 1-13
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes

The authors identify a Cys→Ser transformation (C19S) in insulin leading to neoepitope presentation and CD4⁺ T cell autoreactivity in type 1 diabetes. Inflammation and oxidative stress enhanced C19S transformation in β cells and antigen-presenting cells, resulting in C19S-specific CD4⁺ T cells with an activated memory phenotype linked to disease progression.

Neetu Srivastava
Anthony N. Vomund
Xiaoxiao Wan
ResearchOpen Access28 Nov 2025
Nature Immunology

Volume: 27, P: 82-97
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death

Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4⁺ T cells and dampens autoimmune diabetes.

Pavel N. Zakharov
Chanchal S. Chowdhury
Kodi S. Ravichandran
Research01 Oct 2025
Nature

Volume: 647, P: 1014-1024
The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides

Unanue and colleagues examine the immunopeptidome of pancreatic islets in non-obese diabetic (NOD) mice, which spontaneously develop autoimmune diabetes, to reveal the key features of a restricted component in the self-MHC-II peptidome that causes autoreactivity.

Xiaoxiao Wan
Anthony N. Vomund
Emil R. Unanue
Research09 Mar 2020
Nature Immunology

Volume: 21, P: 455-463
Precession-driven salinity feedback in the western Pacific warm pool: insights from alkenone hydrogen isotopes over the past 450 kyr

Run Yuan
Rui Zhang
Shiyang Xu
ResearchOpen Access27 Jan 2026
npj Climate and Atmospheric Science

Volume: 9, P: 1-12
Effect of regional crosstalk between sympathetic nerves and sensory nerves on temporomandibular joint osteoarthritic pain

Zhangyu Ma
Qianqian Wan
Kai Jiao
ResearchOpen Access07 Jan 2025
International Journal of Oral Science

Volume: 17, P: 1-16
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

A sensitive T cell tracking assay reveals immunogenic activity of specific catabolized peptide fragments of insulin and their effects on T cell activity in lymph nodes, highlighting communication between pancreatic islets and lymphoid tissue.

Xiaoxiao Wan
Bernd H. Zinselmeyer
Emil R. Unanue
Research18 Jul 2018
Nature

Volume: 560, P: 107-111
BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

This resource describes a collection of neurons from a variety of light microscopy-based datasets, which can serve as a gold standard for testing automated tracing algorithms, as shown by comparison of the performance of 35 algorithms.

Linus Manubens-Gil
Zhi Zhou
Hanchuan Peng
Research17 Apr 2023
Nature Methods

Volume: 20, P: 824-835
The significant contribution of biomass burning to methanol-soluble nitrogenous organics and its evolution during the highly-humid haze event in urban Wuhan

Xuehui He
Ping Zeng
Hairong Cheng
ResearchOpen Access01 Jul 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-14
P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways

Xiaoxiao He
Yilu Xu
Junke Zheng
ResearchOpen Access23 Nov 2022
Leukemia

Volume: 37, P: 265-275
Evaluation of Screened Lignin-degrading Fungi for the Biological Pretreatment of Corn Stover

Yingjie Su
Xiaoxiao Yu
Guang Chen
ResearchOpen Access29 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Cryo-EM structures of human calcium homeostasis modulator 5

Jie Liu
Futang Wan
Sheng Ye
CorrespondenceOpen Access10 Nov 2020
Cell Discovery

Volume: 6, P: 1-4

Search

Filter By:

Search

Quick links