Nature Search

Anti-swelling and self-activating artificial proteoglycan assemblies as cartilaginous implant for post-microfracture healing

The insufficient structure and biofunction of cartilaginous implant impede cartilage regeneration. Here, the authors develop anti-swelling and self-activating artificial proteoglycan assemblies for post-microfracture healing by downregulate calcium signaling pathway and reducing ossification.

Zhulian Li
Mingda Zhao
Yong Sun
ResearchOpen Access06 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Flame-retardant electrolytes with electrochemically-inert and weakly coordinating dichloroalkane diluents for practical lithium metal batteries

Lithium metal batteries are restricted by their low safety and poor electrochemical performance. Here, authors present a flame-retardant electrolyte with weakly coordinating dichloroalkane diluents, demonstrating application potential in safer lithium metal batteries in the −60 to +60 °C temperature range.

Zhicheng Wang
Haifeng Tu
Xiaodong Wu
ResearchOpen Access19 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes

PEGylated black phosphorus nanosheets boost mitochondrial oxidative phosphorylation, thereby modulating the survival and immune evasion in tumour cells, and further promoting the activation of immune regulation.

Yuedi Yang
Mingda Zhao
Yong Sun
Research22 Oct 2025
Nature Nanotechnology

Volume: 20, P: 1843-1855
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test

Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients.

Xingdong Chen
Jeffrey Gole
Li Jin
ResearchOpen Access21 Jul 2020
Nature Communications

Volume: 11, P: 1-10
Correction: The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

Bo Yang
Bin Zhang
Quansheng Zhou
Amendments and Corrections06 Apr 2020
Cell Death & Differentiation

Volume: 27, P: 2746
Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Multi-omics data are readily integrated using quartet reference materials.

Yuanting Zheng
Yaqing Liu
Leming Shi
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1133-1149
A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.

Yu Guo
Lisu Huang
Zihe Rao
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-11
Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4

Wei Liu
Yufeng Zhu
Xingdong Zheng
Research28 Jan 2025
Cell Death & Differentiation

Volume: 32, P: 1041-1057
Tuning the apparent hydrogen binding energy to achieve high-performance Ni-based hydrogen oxidation reaction catalyst

Nickel-based electrocatalysts for the hydrogen oxidation reaction in hydroxide exchange membrane fuel cells show promise, but their activity requires further enhancement. Here, the authors report NiCuCr alloy with high activity, owing to the efficient tuning of both hydrogen and water binding on Ni sites by alloying with Cu and Cr.

Xingdong Wang
Xuerui Liu
Zhongbin Zhuang
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Retraction Note: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Pan Jin
Fuqiang Yin
Xingdong Zhang
Amendments and CorrectionsOpen Access20 Jan 2023
Experimental & Molecular Medicine

Volume: 55, P: 281
Synergistic and heterogeneous aging using composite phenotypes and multiple organ systems aging clocks

Li et al. analyze multi-scale phenotypes to investigate heterogeneity in multi-organ aging patterns. They find that accelerated aging in organs such as the cardiovascular system, brain, kidneys, bone, and metabolism is associated with organ-specific links to lifestyle factors, health status, and cardiovascular risk.

Yucan Li
Xinming Xu
Xingdong Chen
ResearchOpen Access01 Dec 2025
Communications Medicine

Volume: 5, P: 1-15
Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors

Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.

Ruyi Yang
Peng Zhao
Jiayi Zhang
Research23 Nov 2023
Nature Biomedical Engineering

Volume: 8, P: 1018-1039
Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification

As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. Here, the authors report a machine learning model using mass spectrometry-based liquid biopsy data for pan-cancer screening and classification.

Hua Zhang
Lin Zhao
Xiangfeng Duan
ResearchOpen Access01 Feb 2022
Nature Communications

Volume: 13, P: 1-11
Path planning of scenic spots based on improved A* algorithm

Xingdong Wang
Haowei Zhang
Donghui Shangguan
ResearchOpen Access25 Jan 2022
Scientific Reports

Volume: 12, P: 1-7
Molecular co-assembled strategy tuning protein conformation for cartilage regeneration

The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures. Here the authors develop a “molecular velcro”-inspired amphiphilic supramolecular co-assembly strategy, which improves the mechanical strength and cartilaginous regeneration efficiency through conformation transition.

Chengkun Zhao
Xing Li
Yong Sun
ResearchOpen Access19 Feb 2024
Nature Communications

Volume: 15, P: 1-14
A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues

The efficacy of drug-eluting stents remains limited due to delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here the authors propose a one-produces-multi stent coating, a drug-free strategy that supports in situ healing of vascular tissues, as demonstrated in rabbit and porcine models.

Haoshuang Wu
Li Yang
Yunbing Wang
ResearchOpen Access25 Jan 2024
Nature Communications

Volume: 15, P: 1-19
A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer

SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expression in squamous cancer.

Yanli Liu
Zhong Wu
Xiaoyang Zhang
ResearchOpen Access08 Dec 2021
Nature Communications

Volume: 12, P: 1-14
Endothelial deletion of PTBP1 disrupts ventricular chamber development

Alternative splicing crucially affects various biological processes, however, its function in heart development is largely unknown. Here, the authors show an essential role of alternative splicing factor PTBP1 in ventricular chamber development.

Hongyu Liu
Ran Duan
Yi-Han Chen
ResearchOpen Access31 Mar 2023
Nature Communications

Volume: 14, P: 1-14
An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis

Limited stem cells and mismatched interface fusion have plagued biomaterial-mediated cranial reconstruction. Here, the authors engineer an instantly fixable and self-adaptive scaffold to promote calcium chelation and interface integration, regulate macrophage M2 polarization, and recruit endogenous stem cells.

Gonggong Lu
Yang Xu
Xingdong Zhang
ResearchOpen Access06 May 2022
Nature Communications

Volume: 13, P: 1-20
Multi-kingdom microbiota analyses identify bacterial–fungal interactions and biomarkers of colorectal cancer across cohorts

Analysis of bacterial, archaeal, fungal and viral species in the gut microbiome of patients with colorectal cancer identified cross-kingdom interactions and multi-kingdom markers of disease.

Ning-Ning Liu
Na Jiao
Hui Wang
ResearchOpen Access27 Jan 2022
Nature Microbiology

Volume: 7, P: 238-250
Hapten Synthesis and the Development of an Ultrasensitive Indirect Competitive ELISA for the Determination of Diethylstilbestrol in Food Samples

Xingdong Yang
Yinbiao Wang
Xianyin Zeng
ResearchOpen Access24 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent Glioblastoma

Xingdong Wang
Yizhi Ge
Hengzhu Zhang
Research01 Mar 2024
Cancer Gene Therapy

Volume: 31, P: 790-801
Solution-Processed Phosphorescent Organic Light-Emitting Diodes with Ultralow Driving Voltage and Very High Power Efficiency

Shumeng Wang
Xingdong Wang
Lixiang Wang
ResearchOpen Access24 Jul 2015
Scientific Reports

Volume: 5, P: 1-9
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells

PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.

Xiangbo Meng
Xiwei Liu
Chenqi Xu
Research28 Nov 2018
Nature

Volume: 564, P: 130-135
Fabrication and mechanical properties of porous tantalum carbon composites by chemical vapor deposition

Junyu Zhu
Wenting Li
Haohong Jiang
ResearchOpen Access21 Jan 2025
Scientific Reports

Volume: 15, P: 1-15
Bidirectional mediation of bone mineral density and brain atrophy on their associations with gait variability

Xin Zhang
Heyang Lu
Xingdong Chen
ResearchOpen Access11 Apr 2024
Scientific Reports

Volume: 14, P: 1-10
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy

Bo Yang
Bin Zhang
Quansheng Zhou
Research06 Mar 2020
Cell Death & Differentiation

Volume: 27, P: 2433-2450
Mechanisms and control of large deformation in mudstone roof gob side entry of inclined coal seams with water softening

Chunyang Tian
Jingchen Chang
Xiangyu Yang
ResearchOpen Access22 Jul 2025
Scientific Reports

Volume: 15, P: 1-22
Rapid Effect of Nitrogen Supply for Soybean at the Beginning Flowering Stage on Biomass and Sucrose Metabolism

Hongli Zhou
Xingdong Yao
Futi Xie
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-13
Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study

Tongchao Zhang
Xiaolin Yin
Weimin Ye
Research24 Feb 2023
Journal of Exposure Science & Environmental Epidemiology

Volume: 33, P: 933-944
Correction: In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects

Tongmeng Jiang
Guojie Xu
Xingdong Zhang
Amendments and CorrectionsOpen Access26 Sept 2019
Cell Death & Disease

Volume: 10, P: 1-2
Extreme sampling design in genetic association mapping of quantitative trait loci using balanced and unbalanced case-control samples

Yi Li
Orna Levran
Chen Suo
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor

Xingdong Guo
Chengsong Yan
Chenqi Xu
Research24 Mar 2017
Cell Research

Volume: 27, P: 505-525
Correction: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Pan Jin
Fuqiang Yin
Xingdong Zhang
Amendments and CorrectionsOpen Access27 Jan 2020
Experimental & Molecular Medicine

Volume: 52, P: 181-182
Author Correction: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Pan Jin
Fuqiang Yin
Xingdong Zhang
Amendments and CorrectionsOpen Access05 Jul 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-2
Oral health in China: from vision to action

Xuedong Zhou
Xin Xu
Xingdong Zhang
ReviewsOpen Access17 Jan 2018
International Journal of Oral Science

Volume: 10, P: 1-6
In vitro expansion impaired the stemness of early passage mesenchymal stem cells for treatment of cartilage defects

Tongmeng Jiang
Guojie Xu
Xingdong Zhang
ResearchOpen Access01 Jun 2017
Cell Death & Disease

Volume: 8, P: e2851
RETRACTED ARTICLE: Guangxi cobra venom-derived NGF promotes the osteogenic and therapeutic effects of porous BCP ceramic

Pan Jin
Fuqiang Yin
Xingdong Zhang
ResearchOpen Access07 Apr 2017
Experimental & Molecular Medicine

Volume: 49, P: e312

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