Nature Search

VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation

Intestinal epithelium is continuously exposed to osmotic changes. Here, the authors show that this volume-regulated anion channel, a key osmo-sensitive ion channel, protects against colitis by balancing nutrient absorption and antimicrobial defense.

Xin Yi
Shiqing Zhang
Pingzheng Zhou
ResearchOpen Access25 Feb 2026
Nature Communications

Volume: 17, P: 1-18
METTL3-based epitranscriptomic editing screening identifies functional m⁶A sites in cancers

He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N⁶-methyladenosine (m⁶A) sites that are important for prostate cancer cells and validate the role of a top m⁶A target, CHD9, in this context.

Xin Xu
Yujuan Wang
Housheng Hansen He
Research06 Feb 2026
Nature Cancer

Volume: 7, P: 469-483
NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer

Yi Tang
Xinpei Deng
Gangjun Yuan
ResearchOpen Access07 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-15
Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice

Exercise could affect the immune system, but whether early-life exercise could benefit immune health in adulthood is not fully understood. Here the authors show that early-life exercise promotes epi-metabolic changes in the liver to potentially benefit immunity in older age and characterise the involvement of pipecolic acid in this process.

Nini Zhang
Xinpei Wang
Feng Gao
ResearchOpen Access10 Apr 2024
Nature Communications

Volume: 15, P: 1-15
N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer

Anti-HER2 resistance causes treatment failure in HER2-positive breast cancers. Here the authors identify FGFR4 as one of the vulnerabilities of anti-HER2 resistant breast cancer and show that FGRR4 inhibition enhances sensitivity to anti-HER2 treatment in these resistant cells by triggering ferroptosis.

Yutian Zou
Shaoquan Zheng
Xiaoming Xie
ResearchOpen Access13 May 2022
Nature Communications

Volume: 13, P: 1-18
The landscape of N⁶-methyladenosine in localized primary prostate cancer

Transcriptome-wide m⁶A RNA methylation profile in 162 primary prostate tumors identifies m⁶A association with prognostic clinical features and disease aggression.

Xin Xu
Helen Zhu
Housheng Hansen He
ResearchOpen Access24 Mar 2025
Nature Genetics

Volume: 57, P: 934-948
Prediction of drug efficacy from transcriptional profiles with deep learning

Drug discovery based on transcriptional profiling does not require knowledge of protein targets.

Jie Zhu
Jingxiang Wang
Zhengwei Xie
Research17 Jun 2021
Nature Biotechnology

Volume: 39, P: 1444-1452
In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Loss of MEN1 affects tumor growth, varing with the components of the tumor microenvironment. These tumors show redistribution of MLL1 on chromatin and the activation of a viral mimicry response.

Peiran Su
Yin Liu
Housheng Hansen He
ResearchOpen Access03 Sept 2024
Nature Genetics

Volume: 56, P: 1890-1902
Disulfidptosis in cancer: from redox stress to therapeutic strategy

Xinpei Deng
Chengyi Zhang
Yutian Zou
Reviews28 Oct 2025
Cancer Gene Therapy

Volume: 33, P: 22-25
CAMK1D activates AMPK/PINK1/Parkin-dependent mitophagy to promote enzalutamide resistance in prostate cancer

Feifei Sun
Ying Qu
Bo Han
ResearchOpen Access19 Dec 2025
Cell Death & Disease

Volume: 17, P: 1-14
Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening

Qiuxia Min
Xinpei Cai
Jiachun Chen
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-9
Transmission of Tomato Yellow Leaf Curl Virus by Bemisia tabaci as Affected by Whitefly Sex and Biotype

Wenxi Ning
Xiaobin Shi
Youjun Zhang
ResearchOpen Access29 May 2015
Scientific Reports

Volume: 5, P: 1-8
Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling

Xinpei Sun
Qian Li
Yu Zhang
ResearchOpen Access29 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-12
ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease

Xinpei Gao
Zhixin Jiang
Congrong Wang
ResearchOpen Access14 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-11
Spatial multi-omics profiling of breast cancer oligo-recurrent lung metastasis

Yang Gao
Bin Li
Xuanwen Bao
Research15 Apr 2025
Oncogene

Volume: 44, P: 2268-2282
CRL4^DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis

Daoyuan Huang
Qian Li
Yu Zhang
Research07 Dec 2020
Cell Death & Differentiation

Volume: 28, P: 1593-1609
RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway

Feifei Sun
Xinpei Wang
Bo Han
Research04 May 2022
Oncogene

Volume: 41, P: 3239-3250
Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancer

Sifeng Qu
Xinpei Ci
Yuzhuo Wang
ResearchOpen Access30 Jan 2018
British Journal of Cancer

Volume: 118, P: 802-812
HiQ-FPAR: A High-Quality and Value-added MODIS Global FPAR Product from 2000 to 2023

Kai Yan
Xinpei Yu
Ranga B. Myneni
ResearchOpen Access15 Jan 2025
Scientific Data

Volume: 12, P: 1-17

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VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammation

METTL3-based epitranscriptomic editing screening identifies functional m⁶A sites in cancers

NSUN2-mediated m5C modification of SOCS3 mRNA modulates macrophage polarization in bladder cancer

Early-life exercise induces immunometabolic epigenetic modification enhancing anti-inflammatory immunity in middle-aged male mice

N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer

The landscape of N⁶-methyladenosine in localized primary prostate cancer

Prediction of drug efficacy from transcriptional profiles with deep learning

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Disulfidptosis in cancer: from redox stress to therapeutic strategy

CAMK1D activates AMPK/PINK1/Parkin-dependent mitophagy to promote enzalutamide resistance in prostate cancer

Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening

Transmission of Tomato Yellow Leaf Curl Virus by Bemisia tabaci as Affected by Whitefly Sex and Biotype

Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling

ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease

Spatial multi-omics profiling of breast cancer oligo-recurrent lung metastasis

CRL4^DCAF8 dependent opposing stability control over the chromatin remodeler LSH orchestrates epigenetic dynamics in ferroptosis

RUVBL1 promotes enzalutamide resistance of prostate tumors through the PLXNA1-CRAF-MAPK pathway

Treatment with docetaxel in combination with Aneustat leads to potent inhibition of metastasis in a patient-derived xenograft model of advanced prostate cancer

HiQ-FPAR: A High-Quality and Value-added MODIS Global FPAR Product from 2000 to 2023

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