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ZFP612 controls neuropathic pain through epigenetic repression of Il1rl1 within the silencer–promoter loop in primary sensory neurons of male mice

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

Longfei Ma
Yangyuxin Huang
Min Yan
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Dynamic decision-making and differential game analysis of ESG-constrained closed-loop supply chains under cap-and-trade regulation

Haiyan Lan
Xinying Si
Jinhuan Tang
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone

The hetero-Diels–Alder reaction is a powerful strategy for constructing six-membered heterocycles, yet natural enzymatic hetero-Diels–Alder reactions are limited to a single heteroatom. Now a bifunctional enzyme, Abx₍₋₎F, is found to catalyse the dehydration and a dual-oxa Diels–Alder reaction to form the oxygen-bridged tricyclic acetal of (−)-anthrabenzoxocinones.

Xiaoli Yan
Xinying Jia
Xudong Qu
Research22 Apr 2025
Nature Chemistry

Volume: 17, P: 1058-1066
Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration

A review summarizes the preparation and regenerative functions of mesenchymal stem cell-derived extracellular matrix (mECM) as a biomimetic material for bone, cartilage, muscle, tendon, and nerve repair, alongside its clinical translation prospects.

Shuqing Lv
Jia Wang
Yong Xu
ReviewsOpen Access31 Jan 2026
Communications Biology

Volume: 9, P: 1-16
Author Correction: A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

Min Zhou
Longqiang Liu
Runhui Liu
Amendments and Corrections30 Apr 2024
Nature Microbiology

Volume: 9, P: 1394
Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage

An alternative diaminopurine (Z) biosynthetic pathway using PurZ0 is found in bacteriophages and used for bacterial immune evasion, with higher structural and biochemical similarities to archaeal PurA than PurZ.

Yang Tong
Xinying Wu
Yan Zhang
Research12 Jun 2023
Nature Microbiology

Volume: 8, P: 1330-1338
Gestational high-sucrose diet mediated vascular hyper-contractility in mesenteric arteries from offspring

Xinying Liu
Meng Liu
Xueqin Feng
ResearchOpen Access17 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2

High-content screening of a natural diterpenoid library identified a highly potent anti-liver fibrosis lead, 12-deoxyphorbol 13-palmitate (DP), which targets apolipoprotein L2 (APOL2) and impairs APOL2–SERCA2–PERK–HES1 signaling.

Lu Gan
Qiwei Jiang
Sheng Yin
Research05 Aug 2024
Nature Chemical Biology

Volume: 21, P: 80-90
Achieving sustainable development goals: coupling coordination between agricultural industrialization and rural infrastructure with the case of China

Yuqing Geng
Yan Yan
Xinying Jiang
ResearchOpen Access25 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-28
Alterations of the skin microbiome in multiple system atrophy: a pilot study

Daji Chen
Lang Sun
Hong Jiang
ResearchOpen Access23 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-6
A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.

Min Zhou
Longqiang Liu
Runhui Liu
Research08 Apr 2024
Nature Microbiology

Volume: 9, P: 1325-1339
Insight-HXMT observations of jet-like corona in a black hole X-ray binary MAXI J1820+070

Evolution of accretion disk and corona during outbursts in black hole binary systems is still unclear. Here, the authors show spectral analysis of MAXI J1820+070 and propose a scenario of a dynamical corona to explain the evolution of the reflection fraction observed by Insight-HXMT.

Bei You
Yuoli Tuo
Yue Zhu
ResearchOpen Access15 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Prenatal diagnosis and molecular cytogenetic characterization of fetuses with central nervous system anomalies using chromosomal microarray analysis: a seven-year single-center retrospective study

Jianlong Zhuang
Na Zhang
Chunnuan Chen
ResearchOpen Access27 Jan 2024
Scientific Reports

Volume: 14, P: 1-8
Toward sustainability: mechanism between work–family balance and fertility intention with decent work as the mediating role

Yuqing Geng
Xinying Jiang
Jianyi Li
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-12
Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients

Zheng Li
Qiuji Wu
Yahua Zhong
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-8
Low-carbon transition and energy poverty: quasi-natural experiment evidence from China’s low-carbon city pilot policy

Yiming Xiao
Zhijun Feng
Shangrui Wang
ResearchOpen Access09 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-18
Frequent KIT Mutations in Human Gastrointestinal Stromal Tumors

Zhi Xu
Xinying Huo
Jinfei Chen
ResearchOpen Access01 Aug 2014
Scientific Reports

Volume: 4, P: 1-9
Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Chenhao Jiang
Teng Yue
Qianqian Li
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Research on stock prediction based on CED-PSO-StockNet time series model

Xinying Chen
Fengjiao Yang
Weiguo Yi
ResearchOpen Access10 Nov 2024
Scientific Reports

Volume: 14, P: 1-28
Gain-of-function PPM1D mutations attenuate ischemic stroke

Wenyan He
Yan Li
Wei-Na Jin
Research21 May 2025
Cell Death & Differentiation

Volume: 32, P: 2146-2159
ROS-activated CXCR2⁺ neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosis

Yaoxian Xiang
Junxi Dai
Jianguang Xu
ResearchOpen Access21 Jul 2022
Experimental & Molecular Medicine

Volume: 54, P: 1011-1023
A dataset of multi-level street-block divisions of 985 cities worldwide

Jintong Tang
Liyan Xu
Yu Liu
ResearchOpen Access19 Mar 2025
Scientific Data

Volume: 12, P: 1-15
Sodium oligomannate disrupts the adherence of Rib^high bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice

Xinyi Wang
Zuoquan Xie
Meiyu Geng
ResearchOpen Access19 Nov 2024
Cell Discovery

Volume: 10, P: 1-19
Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

Kaitong Li
Junyu Cai
Jiannan Feng
ResearchOpen Access07 Aug 2024
Scientific Reports

Volume: 14, P: 1-14
RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination

Lei Yao
Jun Li
Gewen Zhang
ResearchOpen Access11 Apr 2023
Cell Death & Disease

Volume: 14, P: 1-13
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma

Qianqian Zhang
Yingran Gao
Dongdong Wu
Research30 Oct 2022
Oncogene

Volume: 41, P: 5238-5252
Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies

Xiaojuan Chen
Xiaoning Liu
Pei Qin
ReviewsOpen Access20 Aug 2025
Translational Psychiatry

Volume: 15, P: 1-17

Search

ZFP612 controls neuropathic pain through epigenetic repression of Il1rl1 within the silencer–promoter loop in primary sensory neurons of male mice

Dynamic decision-making and differential game analysis of ESG-constrained closed-loop supply chains under cap-and-trade regulation

An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone

Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration

Author Correction: A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage

Gestational high-sucrose diet mediated vascular hyper-contractility in mesenteric arteries from offspring

A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2

Achieving sustainable development goals: coupling coordination between agricultural industrialization and rural infrastructure with the case of China

Alterations of the skin microbiome in multiple system atrophy: a pilot study

A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens

Insight-HXMT observations of jet-like corona in a black hole X-ray binary MAXI J1820+070

Prenatal diagnosis and molecular cytogenetic characterization of fetuses with central nervous system anomalies using chromosomal microarray analysis: a seven-year single-center retrospective study

Toward sustainability: mechanism between work–family balance and fertility intention with decent work as the mediating role

Oral pH value predicts the incidence of radiotherapy related caries in nasopharyngeal carcinoma patients

Low-carbon transition and energy poverty: quasi-natural experiment evidence from China’s low-carbon city pilot policy

Frequent KIT Mutations in Human Gastrointestinal Stromal Tumors

Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Research on stock prediction based on CED-PSO-StockNet time series model

Gain-of-function PPM1D mutations attenuate ischemic stroke

ROS-activated CXCR2⁺ neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosis

A dataset of multi-level street-block divisions of 985 cities worldwide

Sodium oligomannate disrupts the adherence of Rib^high bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice

Unveiling novel insights into human IL-6 − IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis

RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination

Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma

Depression and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies

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