Cycloaddition reaction offers an ideal and powerful method for the construction of cyclic structures with molecular complexity and diversity. Herein, the authors report an asymmetric formal [1 + 2 + 2]-cycloaddition of diazoamides with enamines and carbonyl compounds, synthesizing spiro-tetrahydrofurans containing four consecutive stereocenters.
- Shanliang Dong
- Minghan Yao
- Xinfang Xu
