The epigenetic program underlying the differentiation of innate lymphoid cell precursors (ILCPs) into innate lymphoid cell (ILC) subsets remains poorly understood. Here the authors show genome-wide distribution of the DNA methylation and hydroxymethylation in murine ILC subsets and at postnatal stage, gut microbiota contributes to the downregulation of TET1 level, resulting in an expansion of ILC1s.
- Xusheng Zhang
- Xintong Gao
- Shuo Wang
