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A plasmonic grating-based thermometer translates temperature into fluorescence emission angle shifts. This non-contact method achieves 0.01 °C resolution and effectively isolates thermal signals from environmental interferences.

Reliable sweat induction remains a challenge for wearable sweat biosensing. Here, the authors develop a skin-conformal wearable device that uses ultrasound to induce sweat under resting conditions for electrochemical biomarker tracking.

Ningxia was located at a crossroads between the Eurasian Steppe and East Asia. Here, the authors sequence 89 ancient individuals to reconstructs 4,000 years of genetic history in this region.

Achalasia is a rare condition characterised by inability to swallow. Here, the authors use whole-genome sequencing to identify a FAM129C variant associated with the disease and characterise B cell responses towards the GABA-A receptor in a mouse model expressing that variant.

Here the authors show that PLAGL1 is essential for bone formation from mandibular cells, and losing it hinders regeneration. Epigenetically reactivation of PLAGL1 is proposed as a potential strategy for promoting craniofacial bone healing.

The authors study out-of-time-ordered correlators and Holevo information in a Rydberg atom array, revealing the collapse-and-revival of quantum information in a constrained many-body system.

Preeclampsia is a serious pregnancy complication, but early identification of women at risk remains difficult due to limited biomarkers. Here, the authors show that cell-free DNA fragmentomics from maternal blood can predict preeclampsia risk early in pregnancy.

Deciding between partial nephrectomy (PN) or radical nephrectomy (RN) in patients with complex renal cell carcinoma (RCC) remains a significant clinical challenge. Here, the authors develop an AI model for functional risk stratification in complex RCC using preoperative computed tomography images and clinical data, aiming to assist treatment choice for complex RCC patients, for whom PN is challenging but remains feasible.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

Interleukin-1 receptor-associated kinase 2 (IRAK2) is essential for Myddosome complex formation downstream of most Toll-like receptors. Here, the authors show a loss-of-function copy number variant of IRAK2 associated with immunodeficiency, autoimmunity, and autoinflammation, which disrupts IRAK2 interaction with IRAK4 and further downstream Myddosome formation, accompanied by enhanced interferon responses.

This study achieves high-density potassium niobate ceramics via hot-pressing. It identifies a unique intragranular pore-evolution mechanism driven by lattice diffusion, revealing how these pores dictate the material’s chemical stability.

Heat exposure is associated with increased emergency department visits across multiple territories, with distinct vulnerability patterns by region and cause. These findings inform targeted adaptation strategies and healthcare resource allocation under increasingly severe heat events.

Metabolic reprogramming and the tumor microenvironment (TME) shape pancreatic cancer progression and treatment response. Here, the authors map cell–type–specific metabolic and TME features to define three tumor subtypes with distinct immune profiles and differential responses to existing and proposed therapeutic strategies.

Turning lignin oils into nylon ingredients is hard because key bonds resist breaking and products overreact. A light-driven catalyst makes cyclohexanones without added hydrogen and enables tougher, clearer polyamides.

Peripheral nerve injury lacks effective strategies for synchronous neuromuscular repair. Here, the authors develop a fully implantable self-powered mechano-electrical bioelectronic system (MEBIS) that integrates programmable mechanical stimulation with adaptive electrical signaling to enable coordinated nerve regeneration and muscle preservation, significantly improving functional recovery.

Quantum transport through a single molecule is governed by the formation of short-lived excited states, yet probing these processes remains challenging. Zhang et al. track the dynamics of multiple excited states in a single-molecule radical transistor using nanosecond differential conductance spectroscopy.

Emission-related SDG performance is not just a local issue but shaped by interconnected urban systems, as impacts like greenhouse gases and air pollution cross borders. Inter-city coordination improves outcomes by 11% compared to isolated efforts.

Antibiotics have been used to treat tuberculosis for over 80 years. Here, Chen et al. analyze over 18,000 Mycobacterium tuberculosis genomes to reconstruct the temporal and spatial evolution of drug resistance across China, highlighting the importance of human migration and bacterial adaptation in shaping local epidemics.

A major challenge in single-cell RNAseq analysis is recovering meaningful cell ontology hierarchies and conserved gene modules across datasets. Here, the authors present SuperSCC, a hierarchical clustering framework without data integration, enabling improved annotation and discovery of conserved modules in atlas-scale data.

Bamboo can be processed into high performance structural material if its mechanical strength and homogeneity are enhanced. Here the authors report a strategy to process natural bamboo into a lightweight, robust, and durable structural material with high strengths in longitudinal and transversal directions through bonding network reconstruction.

Polymeric nanoparticles are promising non-lipid-based drug delivery vehicles. However, their clinical translation is limited by poor drug loading capacity and suboptimal delivery efficiency. Here, the authors address these issues by developing Polymeric Coacervate Core Micelles that can efficiently self-assemble and load drug candidates via a “Mix-and-Go” approach.

Noise severely limits quantum communication, particularly in completely depolarizing channels where information transmission is impossible. Here, the authors use a programmable silicon photonic chip to show quantum information transmission through multiple concatenated depolarizing channels by implementing a superposition of cyclic orders, achieving fidelities above the classical qubit threshold in a strongly noisy regime.

Cancer of unknown primary (CUP) represents a heterogenous group of metastatic malignancies with no standard of care following disease progression. Here, the authors report a phase II clinical trial evaluating F520 (anti-PD-1), bevacizumab (VEGF inhibitor) and nab-paclitaxel in the second line setting for patients with cancer of unknown primary.

Acoustic sensing devices are important to realize human‒machine interfaces. Here, the authors report the fabrication of freestanding reduced graphene oxide membranes with a diameter-to-thickness ratio of ~10⁶, leading to a static pressure responsivity of ~ 500 μm/Pa and high-performance microphone applications.

Tumor-associated macrophages and tumor stiffness may both support an immunosuppressive milieu in non-small cell lung cancer, but the underlying crosstalk remains unclear. Here, the authors identify macrophage-derived fibronectin as an immunosuppressive agent, both promoting extracellular matrix stiffness and inducing immunosuppressive immune cells.

Gut bacteria influence where willow leaf beetles lay their eggs. A specific bacterium transmits between insects via damaged host plants, reinforcing egg-laying behaviors linked to offspring performance.

RUNX2⁺ keloid fibroblasts highly expressing ADRB1 produce bone matrix proteins in response to neurotransmitters from catecholaminergic nerves. Blocking this neuro-stromal interaction prevents fibro-osseous reprogramming and keloid progression.

Single-cell multimodal data integration presents a substantial challenge due to the heterogeneous and incomplete modality compositions. Here, the authors introduce Palette, a flexible and interpretable data integration method, enabling the efficient alignment of complex multimodal datasets.

Noise in optoelectronic memories causes harmful overlap of photoconductance states and degrades computing precision. Zhou et al. report an optoelectronic memory that achieves thousands of distinguishable states without denoising, enabling the detection of fast-moving objects.

Fibroblast heterogeneity is a hallmark of fibrosis including in the kidney, but their precise roles in driving renal fibrosis are incompletely understood. Here the authors report that a switch to a CD248⁺ extra cellular matrix -producing fibroblast subset contributes to kidney fibrosis, and blocking CD248 with a monoclonal antibody mitigates the phenotype in male mice.

All-inorganic perovskite solar cells promise strong stability but still suffer from moisture-driven surface damage and limited efficiency. Zhang et al. form a one-dimensional/three-dimensional interface using a tailored salt to stabilize the material and boost performance.

Electronic skins are promising for wearable electronics, though existing fabrication methods have unfavorable processes and mechanical properties. Here the authors utilize a dipping-dipping molecular assembly to fabricate an E-skin in seconds.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

A randomised trial in metformin-treated type 2 diabetes found once-weekly efsubaglutide improved HbA1c and fasting glucose, reduced weight, and enhanced meal-stimulated insulin secretion with mainly mild GI side effects.

Lithium metal batteries face critical challenges such as low ion transport efficiency under lean electrolyte conditions. Here, authors study a bifunctional ligand-bridged electrolyte containing ethyl difluoroacetate that can form interconnected ionic aggregates through hydrogen bonding and lithium-ion coordination interactions, suppressing parasitic reactions and enhancing interfacial charge transfer, enabling stable cycling of a 600 Wh kg-1 lithium metal 14 Ah pouch cell.

Li, Tao, and colleagues present epi-Patho-DBiT to spatially map chromatin accessibility and histone modifications in archived human lymphoma tissues, revealing epigenetic drivers of lymphoma development, progression and transformation.

This study shows that the UMOD p.H36Y mutation promotes kidney inflammation by enabling mutant tubular cells to trigger macrophage pyroptosis through the App–Cd74 pathway.

Artificial intelligence is increasingly used in medical imaging, but its realworld clinical value for report generation is unclear. Here, the authors show that AI assistance in chest X-ray interpretation reduced reading time while maintaining diagnostic accuracy and agreement in a prospective study.

Alternative transcription start sites generate transcript diversity but are difficult to detect due to RNA degradation in 5’ scRNA-seq. Here, the authors present scATS, which corrects degradation to quantify TSS usage, improve cell clustering, and identify lung cancer-promoting TSS isoforms.

Here, the authors uncover a mechanism by which drug-target homologs mediate non-antibiotic drug effects on bacterial growth, and suggest a universal homology-based competition strategy to reverse MTX-induced microbiota dysbiosis.

Ketones are versatile, but converting them to ketyl radicals typically requires harsh conditions. Now a mild method using a bifunctional silyl reagent has been shown to generate ketyl-type radicals through a radical translocation strategy, enabling redox-neutral Pd-catalysed ketone–olefin couplings to give diverse alkenylation and allylation products without requiring organometallic reagents.

High endothelial venules (HEVs) are an underexplored metastatic route. The authors show that breast cancer cells spreading via HEVs are less immunogenic due to ALOX12-driven immune evasion.

Epithelial-mesenchymal transition (EMT) is a common mechanism for acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Here, the authors discover that ZEB1-mediated repression of ELMO3 creates a synthetic-lethal dependence on ELMO2, and that inhibiting ELMO2 selectively kills mesenchymal-like cells and EGFR TKIs–resistant cancer cells.

As presented at the 2026 ASCO Annual Meeting, in a phase 2 trial that included an exploratory and a pivotal phase, treatment of patients with MET-amplified gastric or gastroesophageal junction adenocarcinoma with the selective MET tyrosine kinase inhibitor savolitinib showed promising clinical efficacy.

Difelikefalin is an FDA-approved KOR-targeted drug for chronic pruritus yet exhibits side effects. Here, researchers solve cryo-EM structure of difelikefalin KOR-Gi, identifying Y320^7.43 as a key bias residue. Substituting D-Phe1 with β-phenylalanine develops beta01 which retains analgesic/antipruritic efficacy via a unique receptor conformation that reduces adverse effects.

Zhang et al. report a multifunctional molecule to control the growth of quasi-2D perovskite nanocrystals, reducing defects and ion migration. This enables pure-red LEDs with an efficiency of 30.2%, operational stability of 8426 min, and 12.25 cm² devices maintaining above 20% efficiencies.