The authors defined the role of DNA methyltransferase 1 (DNMT1) during heart failure and identified the underlying mechanism. DNMT1 enhances the methylation of the miR-152-3p promoter region. DNMT1 also enhances the expression of the transcription factor ETS1, which further elevates RhoH expression. DNMT1 therefore induces heart failure by inhibiting mitophagy of in H9c2 cells through regulating the miR-152-3p/ETS1/RhoH axis.
- Zhuojun Deng
- Jiaqi Yao
- Xiaoyong Geng
