This paper introduces OPV, an organic semiconductor material, as a novel photosensitizer to kill intracellular bacteria that are infectious and antibiotic-resistant. It explains how OPV binds to bacterial membranes and produces reactive oxygen species by blue light, guiding photodynamic therapy design. It proves the excellent antibacterial effect of OPV against Porphyromonas gingivalis and MRSA in vitro and in vivo, without damaging normal cells or tissues, indicating good biocompatibility and safety. It also shows that OPV can be excited by dental blue light curing lamps, facilitating clinical applications.
- Lintian Yuan
- Xuancheng Fu
- Yuguang Wang
