The role of cancer associated fibroblasts (CAF) in immunotherapy response of gastric cancer (GC) is elusive. Here, by single cell sequencing, spatial transcriptomic and functional evaluation, the authors identify antigen-presenting CAF (apCAF) with high MHC II, which is correlated with immunotherapy responsiveness of GC patients.
- Junquan Song
- Rongyuan Wei
- Xiaowen Liu
