The high fraction of sp3-hybridized carbon atoms (Fsp3) in cyclobutanes makes them promising bioisosteres for arenes. Now by combining bicyclo[1.1.0]butane C–C activation with remote meta-C–H functionalization, via a ruthenacycle-mediated halogen-atom transfer process, densely decorated Fsp3-rich cyclobutanes can be formed in a single step with high chemo- and position selectivity.
- Shan Chen
- Zhimin Xu
- Lutz Ackermann
